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The vector of anti-EGFRvIII chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human EGFRvIII. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-EGFRvIII antibody linked to 4-1BB and CD3ζ signaling domains. And the vector product was designed for the treatment of Melanoma.
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CAR Construction :
Fig.1 Determination of target specificity of MAbs for EGFRwt and EGFRvIII by flow cytometric analysis. EGFRvIII expressing on NR6M cells. Zalutsky, M. R., Boskovitz, A., Kuan, C. T., Pegram, C. N., Ayriss, J., Wikstrand, C. J., ... & Bigner, D. D. (2012). Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors. Nuclear medicine and biology, 39(1), 23-34. |
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CAR Construction :
Fig.2 Flow cytometric analysis of D2C7-(scdsFv)-PE38KDEL to determine reactivity of the D2C7 IT. Data represented as mean ± SD, n=5. Statistical analysis by two-tailed student's t-test. Chandramohan, V., Bao, X., Keir, S. T., Pegram, C. N., Szafranski, S. E., Piao, H., ... & Bigner, D. D. (2013). Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor TherapyAnti-EGFRwt/EGFRvIII Immunotoxin for Glioblastoma Therapy. Clinical Cancer Research, 19(17), 4717-4727. |
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