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pCDCAR1 BCMA h(28BBζ) (XS-0723-HM6)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-BCMA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human BCMA. The T cells are genetically modified through transduction with a retroviral vector expressing scFv of anti-BCMA antibody linked to CD28, 4-1BB (CD137) and CD3ζ signaling domains. And the vector product was designed for the treatment of multiple myeloma (MM).

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Details

  • Target
  • BCMA
  • Targeting Cell Type
  • T Cell
  • Targeting Diseases
  • Multiple myeloma (MM)
  • Generation
  • Third
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • scFv-CD28-41BB-CD3ζ
  • Discription of Signaling Cassetes
  • CD28
    CD28 (Cluster of Differentiation 28) is one of the proteins expressed on T cells that provide costimulatory signals required for T cell activation and survival. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2) proteins which are expressed on antigen-presenting cells (APC). CD28 modulates the primary TCR/CD3ζ signal in a different fashion than the late costimulatory elements OX40 and 4-1BB. CD28 enhances the expression of downstream regulators that impact on T-cell proliferation, death, differentiation, and effector functions. CAR+ T cells containing the CD28 endodomain showed strikingly enhanced sustained T cell activation, growth, survival. And CD28 results in a brightly expressed, stable receptor as the transmembrane domain. Including CD28 costimulatory domains in CARs led to enhanced anti-malignancy efficacy.
    4-1BB
    CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. On the basis of preclinical observation, this molecule can promote the persistence of antigen-specific and antigennonspecific chimeric antigen receptor T-cells to significantly increases antitumor activity.
    CD3ζ
    CD3ζ, also known as T-cell receptor zeta, which together with T-cell receptor and CD3γ, δ , ε chain, forms the TCR-CD3 complex. ζ was expressed independently from the complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. CD3-zeta, which contains 3 ITAMs, is the most commonly used endodomain component of CARs. It transmits an activation signal to the T cell after antigen is bound. CD3-zeta may not provide a fully competent activation signal and additional co-stimulatory signaling is needed. For example, chimeric CD28 and OX40 can be used with CD11-zeta to transmit a proliferative/survival signal, or all three can be used together.

Target

  • Clone
  • 2C5
  • Host
  • Human
  • Ligand
  • B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL)
  • Receptor
  • BCMA
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • TNFRSF17
  • Synonyms
  • BCMA;TNFRSF17; TNF receptor superfamily member 17; BCM; BCMA; CD269; TNFRSF13A;

Related Resources

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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