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The vector of anti-PSMA chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target Human PSMA. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-PSMA antibody linked to CD28 and CD3ζ signaling domains. And the vector product was designed for the treatment of Prostate cancer.
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CAR Construction :
Fig.1 Binding of the anti-PSMA mAbs 3/A12,3/E7,3/F11,and J591 to C4-2 cells. Cells were incubated with the mAbs,washed to eliminate unbound antibody, stained with goat anti-mouse Ig-RPE as secondary antibody, andanalyzed by flowcytometry. Wolf, P., Freudenberg, N., Bühler, P., Alt, K., Schultze‐Seemann, W., Wetterauer, U., & Elsässer‐Beile, U. (2010). Three conformational antibodies specific for different PSMA epitopes are promising diagnostic and therapeutic tools for prostate cancer. The Prostate, 70(5), 562-569. |
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CAR Construction :
Fig.2 Competitive binding inhibition of biotinylated mAbs 3/E7-B with unmodified mAbs at concentrations reported on the x-axis. C4-2 cells were preincubated with increasing concentrations of non-biotinylated 3/E7, and then incubated with each biotinylated mAb at a concentration of 4 mg/ml. Wolf, P., Freudenberg, N., Bühler, P., Alt, K., Schultze‐Seemann, W., Wetterauer, U., & Elsässer‐Beile, U. (2010). Three conformational antibodies specific for different PSMA epitopes are promising diagnostic and therapeutic tools for prostate cancer. The Prostate, 70(5), 562-569. |
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