Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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EXPLORE MOREAll products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.
The integration of synthetic antigen receptors into immune cells has emerged as a potent approach for treating various diseases, particularly through the use of T cells engineered to express chimeric antigen receptors (CAR) for targeted cancer therapy. However, in addition to T lymphocytes, B lymphocytes also hold great potential as immune cells that can be genetically modified for therapeutic purposes, such as the production of recombinant antibodies or protein replacement therapy. To this end, CAR-B cells are a promising avenue for achieving localized delivery of monoclonal antibodies to tumor sites by targeting specific tumor-associated antigens (TAA).
Creative Biolabs has developed an innovative design for a new class of synthetic antigen receptors, known as chimeric B cell receptors (CBCR). The Anti-TRBC1 (CB-P26) h(scFv-CD28TM-CD79β) CBCR(CAR-B) vector is composed of an anti-TRBC1 antibody-based binding domain, which is fused with the CD79β signaling domain, a component of the B cell receptor (BCR) complex that is responsible for activation. This vector can be introduced into primary murine B cells, resulting in high levels of surface expression and antigen recognition, independent of the endogenous BCR.
There are currently no customer reviews or questions for Anti-TRBC1 (CB-P26 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 (XS-0323-ZP543). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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