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T-cell receptor beta constant 1 (TRBC1) is a protein that in humans is encoded by the TRBC1 gene. The α/β T-cell receptor (TCR) is a pan T-cell antigen, expressed on>90% of T-cell lymphomas and all normal T-cells. An overlooked feature of the TCR is that the β-constant region comprises 2 functionally identical genes: TRBC1 and TRBC2. Each T-cell expresses only one of these. Hence, normal T-cells will be a mixture of individual cells expressing either TRBC1 or 2, while a clonal T-cell cancer will express TRBC1 or 2 in its entirety.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-LC094 | Anti-TRBC1 (Jovi-1) h((CD8stk)-CD28-CD3ζ) CAR, pCDCAR1 | Human | Jovi-1 | Mouse | scFv-(CD8stk)-CD28-CD3ζ | Retroviral | T cell | ||
| CAR-LC095 | Anti-TRBC1 (Jovi-1) h((CH2CH3pvaa)-CD28-CD3ζ) CAR, pCDCAR1 | Human | Jovi-1 | Mouse | scFv-(CH2CH3pvaa)-CD28-CD3ζ | Retroviral | T cell | ||
| CAR-LC096 | Anti-TRBC1 (Jovi-1) h((IgG1)-CD28-CD3ζ) CAR, pCDCAR1 | Human | Jovi-1 | Mouse | scFv-(IgG1)-CD28-CD3ζ | Retroviral | T cell | ||
| CAR-YJ1175 | Anti-TRBC1 (10F499) h(41BB-CD3ζ) CAR, pCDCAR1 | Human | 10F499 | Mouse | scFv-41BB-CD3ζ | Lentiviral vector | T cell | ||
| CAR-YJ1470 | Anti-TRBC1 (10F499) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | 10F499 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T cell | ||
| CAR-0120ZP729 | Anti-TRBC1 ( JOVI-1) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | JOVI-1 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP730 | Anti-TRBC1 ( JOVI-1) h(4-1BB-CD3ζ) CAR, pCDCAR1 | Human | JOVI-1 | Mouse | scFv-4-1BB-CD3ζ | Lentiviral vector | T Cell | ||
| CAR-0120ZP731 | Anti-TRBC1 (CBYJT-4580) h(CD28-CD3ζ) CAR, pCDCAR1 | Human | CBYJT-4580 | Mouse | scFv-CD28-CD3ζ | Lentiviral vector | T Cell | ||
| XS-0622-ZP3229 | Anti-TRBC1 h(VHH1-VHH2-CD28-CD3ζ) Biepitopic CAR, pCDCAR1 | Human | VHH1-VHH2-CD28-CD3ζ | Lentiviral vector | T Cell | ||||
| XS-0622-ZP3401 | Anti-TRBC1 h(VHH1-VHH2-4-1BB-CD3ζ) Biepitopic CAR, pCDCAR1 | VHH1-VHH2-4-1BB-CD3ζ | Lentiviral vector | T Cell | |||||
| XS-0822-YF898 | Anti-Human TRBC1 (XW-898) h(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-898 | Mouse | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF899 | Anti-Mouse TRBC1 (XW-899) m(41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-899 | Rat | scFv-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1818 | Anti-Human TRBC1 (XW-898) h(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-898 | Mouse | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF1819 | Anti-Mouse TRBC1 (XW-899) m(CD28-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-899 | Rat | scFv-CD28-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2738 | Anti-Human TRBC1 (XW-898) h(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Human | XW-898 | Mouse | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0822-YF2739 | Anti-Mouse TRBC1 (XW-899) m(CD28-41BB-CD3ζ) CAR IVT Plasmid, pCARIVT | Mouse | XW-899 | Rat | scFv-CD28-41BB-CD3ζ | In Vitro Transcription (IVT) Vector | |||
| XS-0123-ZP306 | Anti-TRBC1 (IARC307) h(scFv-CD3ε) TRuC, pCDTRC1 | Human | IARC307 | Mouse | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0123-ZP543 | Anti-TRBC1 (CB-P26) h(scFv-CD3ε) TRuC, pCDTRC1 | Mouse | CB-P26 | Rat | scFv-CD3ε | Lentiviral vector | T cell | ||
| XS-0323-ZP306 | Anti-TRBC1 (IARC307 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Human | IARC307 | Mouse | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector | |
| XS-0323-ZP543 | Anti-TRBC1 (CB-P26 scFv-CD28TM-CD79β) CBCR(CAR-B), pCDCAR1 | Mouse | CB-P26 | Rat | scFv-CD28TM-CD79β | Lentiviral vector | T cell | CAR-B Vector |
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CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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