Creative Biolabs has a tradition of commitment. To achieve efficient execution and regulatory approval, we offer careful considerations of your program for the development of a cellular or gene therapy product – now and in the future.
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EXPLORE MORE HighlightsUse the resources in our library to help you understand your options and make critical decisions for your study. We offer oncolytic virus, CAR-T, and dendritic cell related documents, as well as newsletter. If you don't find the answers you're looking for, contact us for additional assistance.
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Sleeping Beauty (SB) transposon, a type of nonviral integrative vectors, provides an alternative to modify primary T cells. Creative biolabs has developed SB transposon CAR vector pSBCAR1 Trop2 (Ab46) h(ICOSBBζ), which is constructed for the engineering of T cells to target human Trop2. The T cells are genetically modified through transduction with a nonviral vector expressing scFv of anti-Trop2 antibody linked to ICOS (CD278) signaling domain and CD137 (4-1BB), CD3-zeta signaling domains. And the vector product was designed for the treatment of epithelial cancers.
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CAR Construction :
Fig.1 TROP2-Ab46 binds to cells that express TROP2 on their surface. |
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CAR Construction :
Fig.2 The inhibitory effect of anti-TROP 2 antibodies on MDA-468 cells, which are TROP2+. |
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There are currently no customer reviews or questions for Anti-Trop2 (Ab46) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 (CAR-SB-02LX656). Click the button below to contact us or submit your feedback about this product.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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