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Tumor-associated calcium signal transducer 2 (Trop2) is a protein in humans is encoded by the TACSTD2 gene. Trop2 was first discovered in trophoblast cells. It is a transmembrane type-1 glycoprotein expressed in multistratified epithelia and several stem/progenitor and carcinoma cells. Trop2 could form an analogous dimer. The incomplete or aberrant production of Trop2 may cause it to lose its function and to be internalized from the membrane into the cytoplasm, where it plays a role in cancer progression. Due to elevated expression levels in carcinoma cells vs. normal tissue, Trop2 has clinical potential both for cancer prognosis and immunotherapy.
Associated Disease
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| CAT | Product Name | Target Species | Antibody Clone | Antibody Host | Receptor Construction | Vector Type | Targeting Cell Type | CAR Vector Type | Inquiry & Datasheet |
| CAR-SB-02LX167 | Anti-Trop2 (Ab40) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | Ab40 | Humanized | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX168 | Anti-Trop2 (Ab50) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | Ab50 | Humanized | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX169 | Anti-Trop2 (Ab7) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | Ab7 | Humanized | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX170 | Anti-Trop2 (Ab22) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | Ab22 | Humanized | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX171 | Anti-Trop2 (Ab51) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | Ab51 | Humanized | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX172 | Anti-Trop2 (Ab46) h(CD28-41BB-CD3ζ) CAR, pSBCAR1 | Human | Ab46 | Humanized | scFv-CD28-41BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX406 | Anti-Trop2 (scFv) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | scFv | Human | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX407 | Anti-Trop2 (TINA1) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | TINA1 | Mouse | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX408 | Anti-Trop2 (Ab8) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab8 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX409 | Anti-Trop2 (Ab40) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab40 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX410 | Anti-Trop2 (Ab50) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab50 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX411 | Anti-Trop2 (Ab7) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab7 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX412 | Anti-Trop2 (Ab22) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab22 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX413 | Anti-Trop2 (Ab51) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab51 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX414 | Anti-Trop2 (Ab46) h(CD28-OX40-CD3ζ) CAR, pSBCAR1 | Human | Ab46 | Humanized | scFv-CD28-OX40-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX648 | Anti-Trop2 (scFv) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | scFv | Human | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX649 | Anti-Trop2 (TINA1) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | TINA1 | Mouse | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX650 | Anti-Trop2 (Ab8) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | Ab8 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX651 | Anti-Trop2 (Ab40) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | Ab40 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell | ||
| CAR-SB-02LX652 | Anti-Trop2 (Ab50) h(ICOS-4-1BB-CD3ζ) CAR, pSBCAR1 | Human | Ab50 | Humanized | scFv-ICOS-4-1BB-CD3ζ | Sleeping Beauty (SB) transposon | T cell |
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NEW SOLUTION
CellRapeutics™ In Vivo Cell Engineering: One-stop in vivo T/B/NK cell and macrophage engineering services covering vectors construction to function verification.
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Silence™ CAR-T Cell: A novel platform to enhance CAR-T cell immunotherapy by combining RNAi technology to suppress genes that may impede CAR functionality.
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Canine CAR-T Therapy Development: From early target discovery, CAR design and construction, cell culture, and transfection, to in vitro and in vivo function validation.
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