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TS-IL15 SA Anti-IL13RA2 (XW-521) 28BBζ CAR (XS-0822-YF10491)

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All products and services are For Research Use Only and CANNOT be used in the treatment or diagnosis of disease.

The vector of anti-Human IL13RA2 chimeric antigen receptor (CAR) is constructed for the engineering of T cells. The receptor construction is 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ. 7H-YB means seven repeats of the HSE motif 5'-nGAAnnTTCnnGAAn-3' upstream of the human synthetic core promoter (YB). 7H-YB is a technology for photothermal control of T cell therapies.

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Details

  • Target
  • IL13RA2
  • Targeting Diseases
  • Glioblastoma; Leptomeningeal Metastases
  • Generation
  • Third-generation CAR
  • Vector Name
  • pCDCAR1
  • Vector Length
  • ~8kb
  • Vector Type
  • Lentiviral vector
  • Receptor Construction
  • 7H-YB-IL15 SA-EF1a-scFv-CD28-41BB-CD3ζ

Target

  • Clone
  • XW-521
  • Host
  • Mouse
  • Target Species
  • Human
  • Gene Name
  • interleukin 13 receptor subunit alpha 2
  • Synonyms
  • CT19; IL-13R; IL13BP; CD213A2
  • Introduction
  • The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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