Anti-ABCA4 Aptamer SELEX Service(Cat#: CTApt-2397)
This is an aptamer development services to screening aptamers binds to the ABCA4 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ABCA4 |
| Alternative Names |
ATP Binding Cassette Subfamily A Member 4; Retinal-Specific Phospholipid-Transporting ATPase ABCA4; ATP-Binding Cassette, Sub-Family A (ABC1), Member 4; ATP-Binding Cassette Transporter, Retinal-Specific; Retinal-Specific ATP-Binding Cassette Transporter ; ATP-Binding Cassette Sub-Family A Member 4; Stargardt Disease Protein; RIM ABC Transporter; RIM Protein; ARMD2; CORD3; ABCR; FFM; ATP-Binding Transporter, Retina-Specifi; ATP Binding Cassette Transporter; Retina-Specific ABC Transporter; Photoreceptor Rim Protein; Stargardt Disease; EC 7.6.2.1; EC 3.6.3; ABC10; STGD1; ABCA4; RP19; STGD; RMP; RmP |
| Gene ID |
24 |
| UniProt ID |
P78363 |
| Target Overview |
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, and the gene product mediates transport of an essental molecule, all-trans-retinal aldehyde (atRAL), across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
