Anti-ABCC5 Aptamer SELEX Service(Cat#: CTApt-2464)
This is an aptamer development services to screening aptamers binds to the ABCC5 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ABCC5 |
| Alternative Names |
ATP Binding Cassette Subfamily C Member 5; MOAT-C; MRP5; SMRP; ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5; Multi-Specific Organic Anion Transporter C; Multidrug Resistance-Associated Protein 5; EST277145; PABC11; Canalicular Multispecific Organic Anion Transporter C; ATP-Binding Cassette Sub-Family C Member 5; ABC33; MOATC; ABCC5 |
| Gene ID |
10057 |
| UniProt ID |
O15440 |
| Target Overview |
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
