Anti-ADRA2A Aptamer SELEX Service(Cat#: CTApt-2405)
This is an aptamer development services to screening aptamers binds to the ADRA2A with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ADRA2A |
| Alternative Names |
Adrenoceptor Alpha 2A; ADRAR; Alpha-2 Adrenergic Receptor Subtype C10; Adrenergic, Alpha-2A-, Receptor; Alpha-2A Adrenergic Receptor; Alpha-2A Adrenoreceptor; Alpha-2AAR Subtype C10; Alpha-2A Adrenoceptor; ADRA2R; Alpha-2-Adrenergic Receptor, Platelet Type; Alpha-2A-Adrenergic Receptor; Alpha-2AAR; ALPHA2AAR; ADRA2A; ADRA2; ZNF32 |
| Gene ID |
150 |
| UniProt ID |
P08913 |
| Target Overview |
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. The alpha-2-adrenergic receptors are a type of adrenergic receptors (for adrenaline or epinephrine), which inhibit adenylate cyclase. These receptors include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. They are involved in regulating the release of neurotransmitter molecules from sympathetic nerves and from adrenergic neurons in the central nervous system. The sympathetic nervous system regulates cardiovascular function by activating adrenergic receptors in the heart, blood vessels and kidney. Studies in mouse revealed that both the alpha2A and alpha2C receptor subtypes were required for presynaptic transmitter release from the sympathetic nervous system in the heart and from central noradrenergic neurons. The alpha-2-adrenergic receptors are also involved in catecholamine signaling by extracellular regulated protein kinase 1 and 2 (ERK1/2) pathways. A clear association between the alpha-2-adrenergic receptor and disease has not been yet established. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
