Anti-ALX4 Aptamer SELEX Service(Cat#: CTApt-2516)
This is an aptamer development services to screening aptamers binds to the ALX4 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
ALX4 |
| Alternative Names |
ALX Homeobox 4; Homeobox Protein Aristaless-Like 4; Aristaless-Like Homeobox 4; KIAA1788; Homeodomain Transcription Factor ALX4; Parietal Foramina 2; CRS5; FND2; ALX4; FPP; PFM |
| Gene ID |
60529 |
| UniProt ID |
Q9H161 |
| Target Overview |
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, cognitive disability, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
