Anti-CD124 Aptamer(Cat#: CTApt-M-939)
This product is an aptamer which binds to the CD124 with an affinity of <20 nM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
CD124 |
| Alternative Names |
Interleukin 4 Receptor; CD124; Interleukin-4 Receptor Subunit Alpha; IL-4 Receptor Subunit Alpha; Interleukin 13 Receptor ; IL-4R ; IL4RA ; Interleukin-4 Receptor Alpha Chain ; IL4R Nirs Variant 1 ; IL-4R Subunit Alpha ; CD124 Antigen; IL-4R-Alpha |
| Gene ID |
3566 |
| UniProt ID |
P40763 |
| Target Overview |
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
| Chemical Modification |
2'F-RNA |
| Length |
60-80 nt |
| Affinity (Kd) |
<20 nM |
| Binding Conditions/Buffer |
TrisHCl Ph7.4 33mM, 66mM KCH3CO2, 10mM MgCH3CO2, 500µM DTT, 1 mM ATP. |
| GC Content |
0.61 |
| Molecular Weight |
24481.7 |
| nmoles/OD260 |
1.105 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
