This product is an aptamer that binds to the Human Matrix Metalloproteinase 9 (MMP9) protein with an affinity of <50 nM.
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Target Category | Protein |
Target | MMP9 |
Alternative Names | Matrix Metallopeptidase 9; CLG4B; Matrix Metalloproteinase 9 (Gelatinase B; 92kDa Gelatinase; 92kDa Type IV Collagenase); Matrix Metalloproteinase-9; EC 3.4.24.35; MMP-9; GELB; Matrix Metallopeptidase 9 (Gelatinase B; 92kDa Gelatinase; 92kDa Type IV Collagenase); 92 KDa Type IV Collagenase; Macrophage Gelatinase; Type V Collagenase; 92 KDa Gelatinase; Gelatinase B; EC 3.4.24; MANDP2 |
Gene ID | 4318 |
UniProt ID | P14780 |
Target Overview | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and Mouse studies suggest a role in tumor-associated tissue remodeling. |
Type | DNA |
Species Reactivity | Human |
Length | 50-200 nt |
Affinity (Kd) | <50 nM |
Binding Conditions/Buffer | 20 mM MOPS, 150mM NaCl, 1 mM CaCl₂ |
GC Content | 43.90% |
Molecular Weight | 12149.95 g/mole |
nmoles/OD260 | 2.97 |