Anti-Human NFKB1 Aptamer (CTMM-0124-LH31)

Specifications

Target Category	Protein
Target	NFKB1
Alternative Names	Nuclear Factor Kappa B Subunit 1; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1; Nuclear Factor NF-Kappa-B P105 Subunit; NFKB-P50; NF-KB1; KBF1; DNA-Binding Factor KBF1; NF-KappaB; NFkappaB; EBP-1; P105; P50; Nuclear Factor Kappa-B DNA Binding Subunit; Nuclear Factor NF-Kappa-B P50 Subunit; NF-Kappabeta; NF-Kappa-B1; NFKB-P105; NF-KAPPAB; NFKAPPAB; CVID12; NF-KB
Gene ID	4790
UniProt ID	P19838
Target Overview	This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.
Chemical Modification	2'-O-methyl oligonucleotides
Type	RNA
Species Reactivity	Human
Length	50-100 nt
Affinity (Kd)	200-1000 pM
Binding Conditions/Buffer	200 mM Tris-HCl, 2.5 mM EDTA, 300 mM NaCl, 2% SDS, pH=7.6
GC Content	40.00%
Molecular Weight	31672.9 g/mole
nmoles/OD260	0.833

Anti-Human NFKB1 Aptamer(Cat#: CTMM-0124-LH31)