Anti-PTPN11 Aptamer(Cat#: CTWZ-0124-WZ44)
This product is an aptamer which binds to PTPN11 with an affinity of 1-50 nM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
PTPN11 |
| Alternative Names |
Protein Tyrosine Phosphatase Non-Receptor Type 11; SH-PTP2; PTP2C; BPTP3; SHP-2; SHP2; SH2 Domain-Containing Protein Tyrosine Phosphatase 2; Tyrosine-Protein Phosphatase Non-Receptor Type 11; Protein-Tyrosine Phosphatase 1D; Protein-Tyrosine Phosphatase 2C; EC 3.1.3.48; SH-PTP3; PTP-1D; NS1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Noonan Syndrome 1; METCDS; SHPTP2; PTP-2C; JMML; Shp2; CFC |
| Gene ID |
5781 |
| UniProt ID |
Q06124 |
| Target Overview |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. |
| Type |
DNA |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| GC Content |
58.54% |
| Molecular Weight |
25093.3 g/mole |
| nmoles/OD260 |
1.162 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
