Anti-Yeast TBP Aptamer(Cat#: CTWZ-0124-WZ54)
This product is an aptamer which binds to yeast TBP with an affinity of 1-50 nM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
TBP |
| Alternative Names |
TATA-Box Binding Protein; TFIID; GTF2D1; TBP1; Transcription Initiation Factor TFIID TBP Subunit; TATA Sequence-Binding Protein; TATA-Box-Binding Protein; TATA-Box Factor; SCA17; TATA-Box Binding Protein N-Terminal Domain; Spinocerebellar Ataxia 17; TATA-Binding Factor; GTF2D; HDL4; TF2D |
| Gene ID |
6908 |
| UniProt ID |
P20226 |
| Target Overview |
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Yeast |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
12 mM Hepes, 60 mM potassium chloride, 5 mM magnesium chloride, 1 mM EDTA, pH 7.9 |
| GC Content |
51.49% |
| Molecular Weight |
30282.3 g/mole |
| nmoles/OD260 |
0.903 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
