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Dengue Virus S4 Virus-like Particles (DENV S4 VLPs) (CAT#: VLP-015YF)

Datasheet
Recombinant Dengue Virus serotype 4 Virus-like Particle (DENV S4 VLPs) are produced in mammalian HEK293 human cells, assembled with Envelope, pre-Membrane and Membrane proteins. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. DENV S4 VLPs can be used in the development of DENV diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • Capsid protein C, membrane protein M, envelope protein E
  • Expression Systems
  • HEK293 (please specify if other expression system is needed)
  • Purity
  • >95%
  • Buffer
  • PBS pH7.4, 30% sucrose
  • Form
  • Liquid
  • Alternative Names
  • Dengue Virus S4 Virus-like Particle; DENV S4 VLPs; VLPs; Virus-like Particles; DENV Serotype 4; Dengue Virus Serotype 4
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Flaviviridae
  • Virus Species
  • Dengue virus
  • Virus Overview
  • The DENV genome is about 11000 bases of positive-sense, single stranded RNA (ssRNA) that codes for three structural proteins (capsid protein C, membrane protein M, envelope protein E) and seven nonstructural proteins (NS1, NS2a, NS2b, NS3, NS4a, NS4b, NS5). It also includes short noncoding regions on both the 5' and 3' ends. Dengue virus (DENV) is the cause of dengue fever. It is a mosquito-borne, single positive-stranded RNA virus of the family Flaviviridae; genus Flavivirus. Five serotypes of the virus have been found, all of which can cause the full spectrum of disease.
  • Virus Structure
  • Enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Dengue disease

Customer reviews and Q&As    

Customer Review

Better reactivity in ELISA assay

Among the diagnostic methods developed for DENV S4, DENV S4 VLP showed better response in ELISA assay.
2022-12-14

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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