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Mayaro Virus-like Particles (MAYV VLPs) (CAT#: VLP-019YF)

Datasheet
Recombinant Mayaro Virus-like Particles (MAYV VLPs) are produced in mammalian HEK293 human cells, assembled with E1, E2 and capsid proteins. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. MAYV VLPs can be used in the development of MAYV diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • E1, E2 and capsid protein
  • Expression Systems
  • HEK293 (please specify if other expression system is needed)
  • Purity
  • >90%
  • Buffer
  • DPBS, pH7.4
  • Form
  • Liquid
  • Alternative Names
  • Mayaro Virus-like Particles; MAYV VLPs; Mayaro Virus; MAYV; VLP; Virus-like particle
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Togaviridae
  • Virus Species
  • Mayaro Virus
  • Virus Strain
  • Acre27
  • Virus Overview
  • Mayaro virus disease is caused by the Mayaro virus infection, an acute, self-limited dengue-like illness of 3-5 days' duration. Mayaro virus, also known as MAYV, is in the family Togaviridae, and genus Alphavirus. It is closely related to other alphaviruses that produce a dengue-like illness accompanied by long-lasting arthralgia. It is only known to circulate in tropical South America. It's an enveloped, linear, positive-sense, single-stranded RNA virus. The MAYV genome consists of 5' untranslated region, 3' noncoding region, and two open reading frames (ORFs). The 5'-proximal ORF encodes for nonstructural proteins (nsP1, nsP2, nsP3, nsP4) and the 3'-proximal ORF with a 26S promoter encodes for structural proteins (capsid proteins and envelope surface glycoproteins, E1, E2, E3, C, 6K). The MAYV infection is characterized by fever, headache, myalgia, rash, prominent pain in the large joints, and association with rheumatic disease, but these signs and symptoms are unspecific to distinguish from other arboviruses. The MAYV infection can be confirmed by laboratory testing such as virus isolation, RT-PCR, and serology.
  • Virus Structure
  • Enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Mayaro virus disease

Customer reviews and Q&As    

Customer Review

MAYV VLP induces a strong immune response

MAYV VLP is capable of acting as a direct immunogen to induce strong cellular and humoral responses.
2022-12-18

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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