GABRB2 Membrane Protein Introduction

Introduction of GABRB2

Gamma-aminobutyric acid receptor subunit beta-2 (GABRB2), also known as GABA(B) receptor subunit beta-2, is a protein that in humans is encoded by the GABRB2 gene. It is a member of the GABAA receptors family, which are ligand-gated Cl⁻ channels responsible for most of the physiological actions of GABA. During the past years, functions and applications of GABRB2 have been widely studied.

Basic Information of GABRB2
Protein Name	Gamma-aminobutyric acid receptor subunit beta-2
Gene Name	GABRB2
Aliases	GABA(B) receptor subunit beta-2
Organism	Homo sapiens (Human)
UniProt ID	P47870
Transmembrane Times	4
Length (aa)	512
Sequence	MWRVRKRGYFGIWSFPLIIAAVCAQSVNDPSNMSLVKETVDRLLKGYDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSYNVIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVFSTGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEKAASANNEKMRLDVNKIFYKDIKQNGTQYRSLWDPTGNLSPTRRTTNYDFSLYTMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSIQYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYWLYYVN

Function of GABRB2 Membrane Protein

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain, which exerts its inhibitory activity by binding to two types of receptors (GABAA and GABAB receptors). GABRB2, one of the principal components of most native GABAA receptors, is found in two alternatively spliced isoforms, namely the short isoform β2S and the long isoform β2L. The long isoform is more prone than the short isoform to current run-down induced by repetitive activation. It has been reported that GABRB2 has the ability to regulate the intracellular Ca²⁺ concentration, which is important for the nervous system. What’s more, studies have shown that GABRB2 is significantly associated with diverse psychotic disorders, including autism, bipolar disorder, epilepsy, schizophrenia, and alcohol and heroin dependence.

Fig.1 Novel mechanism regulating GABAB receptor signaling by disrupting the functional receptor heterodimer via interaction with 14-3-3ζ. (Benke, 2012)

Application GABRB2 of Membrane Protein in Literature

Zhang T., et al. Meta-analysis of GABRB2 polymorphisms and the risk of schizophrenia combined with GWAS data of the Han Chinese population and psychiatric genomics consortium. PloS one. 2018, 13(6):e0198690. PubMed ID: 29894498

This article suggests that GABRB2 polymorphisms might not be associated with Schizophrenia.
Jin Y., et al. GABRB2 plays an important role in the lymph node metastasis of papillary thyroid cancer. Biochemical and biophysical research communications. 2017, 492(3):323-30. PubMed ID: PubMed ID: 29894498

This study aims to investigate the role of GABRB2 in cancer. It suggests that GABRB2 plays important tumorigenic functions and acts as a novel oncogene in papillary thyroid carcinoma.
Zong L., et al. Genetic and epigenetic regulation on the transcription of GABRB2: genotype-dependent hydroxymethylation and methylation alterations in schizophrenia. Journal of psychiatric research. 2017, 88:9-17. PubMed ID: 28063323

This article reveals that alterations in GABRB2 genotype-dependent methylation and hydroxymethylation in schizophrenia, which yields transcriptional and translational alterations in the cultured cells and helps elucidate the genetic-epigenetic interactions influencing schizophrenia.
Wang L., et al. DNA methylation regulates gabrb2 mRNA expression: developmental variations and disruptions in l-methionine-induced zebrafish with schizophrenia-like symptoms. Genes, Brain, and Behavior. 2016, 15(8):702-10. PubMed ID: 27509263

This study aims to investigate the relationship between the gabrb2 mRNA expression and its promoter DNA methylation in the developmental and MET-induced schizophrenia-like zebrafish model. It suggests that GABAA receptor β2 subunit is involved in the schizophrenia-like behaviors and demonstrates the potential use of zebrafish models in neuropsychiatric research.
Kim Y.S., et al. GABRB2 haplotype association with heroin dependence in Chinese population. PloS one. 2015, 10(11):e0142049. PubMed ID: 26561861

This article indicates that the schizophrenia candidate gene GABRB2 plays a role in heroin dependence.

GABRB2 Preparation Options

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Reference

Benke D, et al. (2012). Divorce of obligatory partners in pain: disruption of GABAB receptor heterodimers in neuralgia. The EMBO journal, 31(15), 3234-3236.

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