GABRP Membrane Protein Introduction

Introduction of GABRP

Gamma-aminobutyric acid receptor subunit pi (GABRP), also known as GABA(A) receptor subunit pi, is a protein that in humans is encoded by the GABRP gene. The amino acid sequence of the pi subunit is most closely related to GABAA receptor β- and δ-subunits, and is less similar to other GABAA receptor or glycine receptor subunits.

Basic Information of GABRP
Protein Name	Gamma-aminobutyric acid receptor subunit pi
Gene Name	GABRP
Aliases	GABA(B) receptor subunit pi
Organism	Homo sapiens (Human)
UniProt ID	O00591
Transmembrane Times	4
Length (aa)	440
Sequence	MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPGFENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLANVFYWAYYMYF

Function of GABRP Membrane Protein

The pi-subunit of the g-aminobutyric acid (GABA) receptor, encoded by the gene GABRP, is a transmembrane protein that belongs to the GABA(A) receptors family. The polypeptide of GABRP has all of the hallmarks of a ligand-gated anion channel subunit. However, unlike other GABA(A) subunits, GABRP is not abundant in the brain but is detectable in multiple non-neuronal normal human tissues, including the mammary gland, prostate gland, lung, thymus, and uterus. It has been reported that GABRP is also highly expressed in certain types of cancer such as pancreatic ductal adenocarcinoma and basal-like breast cancer. Furthermore, there is progressive downregulation in concordance with tumor progression in sporadic breast cancer tissues. And, expression of GABRP is also associated with the basal-like/triple negative subtype, brain metastases, and poorer prognosis.

Fig.1 Schematic representation of GABAAR and the GABAergic synapse. (Farb, 2014)

Application GABRP of Membrane Protein in Literature

Sung H.Y., et al. Aberrant epigenetic regulation of GABRP associates with an aggressive phenotype of ovarian cancer. Experimental & molecular medicine. 2016, 48(4):e335. PubMed ID: 28524180

This article suggests that GABRP could enhance the aggressive phenotype of ovarian cancer cells, and the DNA methylation status of the GABRP-963 CpG site may be useful for predicting the metastatic potential in ovarian cancer patients.
Kim H.S., et al. The association of the GABRP polymorphisms with systemic lupus erythematosus. Journal of immunology research. 2015, 2015:602154. PubMed ID: 26634217

This article aims to validate whether the polymorphisms in the GABRP gene are associated with the susceptibility to systematic lupus erythematosus (SLE). It suggests that the polymorphisms in the GABRP gene might be associated with the susceptibility to SLE and the haplotype of GABRP SNPs is a useful genetic marker for SLE.
Sizemore G.M., et al. GABA (A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular regulated kinase 1/2 (ERK1/2). Journal of Biological Chemistry. 2014, 289(35):24102-24113. PubMed ID: 25012653

This article suggests that a GABRP-ERK1/2-cytokeratin axis that maintains the migratory phenotype of basal-like breast cancer. GABRP is a component of a cell surface receptor, thus, these findings indicate that targeting this new signaling axis may have therapeutic potential in basal-like breast cancer.
Zafrakas M., et.al. Systematic characterization of GABRP expression in sporadic breast cancer and normal breast tissue. International journal of cancer. 2006, 118(6):1453-9. PubMed ID: 16187283

This article suggests that GABRP is progressively down-regulated with tumor-progression and that it may be useful as a prognostic marker in breast cancer.

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Reference

Farb, et al. (2014). Targeting the modulation of neural circuitry for the treatment of anxiety disorders. Pharmacological reviews. 66(4), 1002-1032.

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