GABRR1 Membrane Protein Introduction

Introduction of GABRR1

The Gamma-aminobutyric acid receptor subunit rho-1(GABRR1), which in humans is encoded by the GABRR1 gene, is also known as a GABA-ρ receptor. GABA is the major inhibitory neurotransmitter in the vertebrate brain, mediating neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA(A) receptor subunit rho-1 can play an important role in retinal neurotransmission.

Basic Information of GABRR1
Protein Name	Gamma-aminobutyric acid receptor subunit rho-1
Gene Name	GABRR1
Aliases	GABA(A) receptor subunit rho-1, GABA(C) receptor
Organism	Homo sapiens (Human)
UniProt ID	P24046
Transmembrane Times	4
Length (aa)	480
Sequence	MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS

Function of GABRR1 Membrane Protein

GABA is the major inhibitory neurotransmitter throughout most of the mature nervous system. Three types of GABA receptors are reported: GABA_A, GABA_B, and GABA_C (GABRR1) receptors. The GABRR1, a postsynaptic membrane receptor expressed prominently in the retina, is a ligand-gated ion channel that consists of a combination of ρ subunits. GABRR1 belongs to the Cys-loop superfamily of ligand-gated ion channels. GABRR1 are expressed mainly in the retina, although they have been identified in a variety of central nervous systems. GABRR1 are pentameric, sharing common structural characteristics with other Cys-loop receptor members. Three isoforms of GABA_C-ρ subunits (ρ1, ρ2 and ρ3) have been identified in human. The ρ subunits can form homopentameric GABRR1. The GABRR1, a sub-family of GABA_A, consist of ρ subunits and are expressed in brain tissue, with especially high expression in retina. The availability of an antibody to the human GABA_C ρ1 subunit would facilitate research on ρ1-containing GABA_C receptors, and potentially also clinical studies aimed at selectively targeting tissues rich in ρ1.

Fig.1 The structure of GABA receptor.

Application of GABRR1 Membrane Protein in Literature

Koussoulas K., et al. Neurally Released GABA Acts via GABA_C Receptors to Modulate Ca²⁺ Transients Evoked by Trains of Synaptic Inputs, but Not Responses Evoked by Single Stimuli, in Myenteric Neurons of Mouse Ileum. Frontiers in Physiology. 2018, 9:97. PubMed ID: 29487540

The article suggests a novel role for GABA_C receptors in modulating slow synaptic transmission, as indicated by changes in [Ca²⁺]i transients, within the ENS.
Govindpani K., et al. Towards a Better Understanding of GABAergic Remodeling in Alzheimer’s Disease. International Journal of Molecular Sciences. 2017,18(8): 1813. PubMed ID: 28825683

The article suggests that changes in GABAergic function could be an important factor in both early and later stages of AD pathogenesis.
Li Z., et al. Metabolic Pathways Regulated by Γ-Aminobutyric Acid (GABA) Contributing to Heat Tolerance in Creeping Bentgrass (Agrostis Stolonifera). Scientific Reports. 2016, (6): 30338.PubMed ID: 27455877

The article reveals that the increased GABA shunt could be the supply of intermediates to feed the tricarboxylic acid cycle of respiration metabolism during a long-term heat stress, thereby maintaining metabolic homeostasis.
Albers H.E., et al. The Dynamics of GABA Signaling: Revelations from the Circadian Pacemaker in the Suprachiasmatic Nucleus. Frontiers in neuroendocrinology. 2017, (44): 35-82. PubMed ID: 27894927

This review considers the role of GABA in the circadian pacemaker, in the mechanisms responsible for the generation of circadian rhythms, in the ability of non-photic stimuli to reset the phase of the pacemaker, and in the ability of the day-night cycle to entrain the pacemaker.
Carpenter T.S., et al. An Electrostatic Funnel in the GABA-Binding Pathway.Ed. Michael Nilges. PLoS Computational Biology. 2016, (12.4): e1004831. PubMed ID: 27119953

The authors define a nuanced mechanism whereby the GABAA-R uses the general zwitterionic features of the GABA molecule to identify a potential ligand some 2 nm away from the binding site.

GABRR1 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GABRR1 antibody development services.

Creative Biolabs' skillful scientists are glad to leverage our expertise and advanced technologies to help you with the member protein research. If you are interested, please feel free to contact us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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