shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(BBS5-shRNA-Seq2)(CAT#: AdV-SI3212WQ)
This product is a BBS5-shRNA encoding AdV, which is based on AdV-5 serotype with E1/E3 gene deleted. The BBS5 gene encodes a protein that has been directly linked to Bardet-Biedl syndrome. The primary features of this syndrome include retinal dystrophy, obesity, polydactyly, renal abnormalities and learning disabilities. The expression of BBS5-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | AdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Modification | ΔE1/E3 |
Insert | BBS5-shRNA-Seq2 |
Related Target/Protein | BBS5 |
Region | CDS |
TargetSeq | GTGGATATGTTCTTGGCTTTA |
NCBI RefSeq | NM_152384 |
Titer | >1*10^10 GC/mL |
Related Diseases | Bardet-Biedl syndrome |