CRISPR based Screening Solutions

CRISPR-based screening is a cutting-edge, high-throughput approach that uses CRISPR-Cas systems to systematically explore gene function by modulating gene expression at the genomic level. This approach is increasingly recognized as a powerful tool for functional genomics, allowing scientists to uncover genes essential for cell survival, drug resistance, immune modulation, or disease progression. To support these advanced research needs, Creative Biolabs provides a full suite of CRISPR-based screening services, with optimized platform for both commercial and custom library screens, adaptable to a wide range of cell types and phenotypic readouts.

Introduction of CRISPR based Screening Solution

CRISPR-based screening is a powerful high-throughput strategy that harnesses the accuracy and programmability of CRISPR-Cas systems—including CRISPRko, CRISPRa, and CRISPRi—to dissect gene function across the genome. By introducing large-scale sgRNA libraries targeting coding genes, non-coding RNAs, and regulatory elements, researchers can map functional networks and identify context-specific vulnerabilities in various cell types and disease models. It supports diverse phenotypic outputs, from cell viability to multi-omics readouts, offering key insights into gene roles under different biological contexts. Compared to RNAi or overexpression methods, CRISPR offers higher specificity, lower off-target effects, and supports both gain- and loss-of-function screening, making it the preferred tool for large-scale genetic interrogation and translational research. By selecting different sgRNA libraries—whether genome-wide, pathway-specific, or custom-designed—researchers can perform screening at various levels, from broad discovery to focused functional validation.

Advantages of CRISPR based Screening Solution

Fig. 1 Advantages of CRISPR based screening solution.

• High Specificity & Precision - CRISPR systems allow for targeted gene modulation with minimal off-target effects, enabling accurate identification of gene functions and interactions.
• Versatile Functional Modulation - Supports both loss-of-function (CRISPRko, CRISPRi) and gain-of-function (CRISPRa) studies, offering flexible screening options across various biological contexts.
• Scalable for High-Throughput - Compatible with genome-wide and focused libraries, CRISPR screens can be applied in commercial and custom library, making them ideal for both exploratory and targeted studies.
• Broad Application Scope - Widely used in oncology, immunology, neuroscience, infectious diseases, and drug discovery, CRISPR screening supports applications from basic research to translational medicine.
• Multi-Layered Readouts - Adaptable to diverse phenotypic outputs, including cell viability, fluorescence, reporter assays, and multi-omics approaches and analysis.

What We Can Do

With the rapid rise of CRISPR-based screening as a gold-standard tool in functional genomics, drug discovery, and precision medicine, researchers worldwide are turning to this technology for its unparalleled precision, flexibility, and scalability. At Creative Biolabs, we offer a well-established CRISPR screening platform powered by advanced technologies and a highly experienced scientific team. Our solutions are designed to meet the various demands, delivering reliable, reproducible, and high-throughput results across a wide range of biological systems. We provide comprehensive end-to-end CRISPR screening services, including:

• Genome-Wide CRISPR Screening
• CRISPRa Screening
• CRISPRi Screening
• Single-Cell CRISPR Screening
• Custom CRISPR Screening

Whether you aim to uncover gene function, identify drug targets, or map regulatory networks, Creative Biolabs is ready to support your research with precision, speed, and scientific excellence. Contact us today to learn how our CRISPR-based screening solutions can drive your discovery forward.