shRNA Adenovirus Serotype 5 (ΔE1/E3), p7SK-(WDR74-shRNA-Seq1)(CAT#: AdV-SI1453WQ)
This product is a WDR74-shRNA encoding AdV, which is based on AdV-5 serotype with EIB-55K gene deleted. The WDR74 gene participates in an early cleavage of the pre-rRNA processing pathway in cooperation with NVL and is required for blastocyst formation, is necessary for RNA transcription, processing and/or stability during preimplantation development. The expression of WDR74-shRNA leads to target gene silencing and this product can be used in gene therapy research and development.
Specifications | |
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Family | Adenoviridae |
Species | Adenovirus |
Serotype | HAdV-5 |
Backbone | AdV-5 (ΔE1/E3) |
Tropism | Both nondividing and dividing cells |
Insert | WDR74-shRNA-Seq1 |
Related Target/Protein | WDR74 |
Region | CDS |
TargetSeq | CTAGAAGACACAGAGACAGAT |
NCBI RefSeq | NM_018093 |
Alternative Names | Nsa1 |
Titer | >1*10^10 GC/mL |
Related Diseases | Mammary adenocarcinoma |