GRID1 Membrane Protein Introduction

Introduction of GRID1

Glutamate receptor delta-1 subunit (GRID1) is also known as GluR delta-1 subunit. The protein is encoded by the GRID1 gene in humans, which encodes a subunit of the glutamate receptor ligand-gated ion channel. These channels regulate most of the fast-excitatory synaptic transmission in the central nervous system (CNS) and are required in synaptic plasticity. Several genetic epidemiology studies have shown a strong relationship between several variants of the GRID1 gene and an increased risk of developing schizophrenia. The glutamate delta-1 (GluD1) receptor is highly expressed in the forebrain. Loss of GluD1 leads to social and cognitive deficits in mice.

Basic Information of GRID1
Protein Name	Glutamate receptor ionotropic, delta-1
Gene Name	GRID1
Aliases	GluD1, GluR delta-1 subunit, KIAA1220
Organism	Homo sapiens (Human)
UniProt ID	Q9ULK0
Transmembrane Times	3
Length (aa)	1009
Sequence	MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLLCDPQEGYLQMLQISNLYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSLQERPMGSRLQGLTLKVVTVLEEPFVMVAENILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQPRPSASATLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQISPASIELSALEMGGLAPTQTLEPTREYQNTQLSVSTFLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSMQCKHRSPNGGLFRQSPVKTPIPMSFQPVPGGVLPEALDTSHGTSI

Function of GRID1 Membrane Protein

Several diseases are related to GRID1 including Rett syndrome and bipolar I disorder. Among the related pathways of the gene are Peptide ligand-binding receptors and MECP2 and Associated Rett Syndrome. Genome-wide association studies indicate that the variations in the GRID1 gene are associated with bipolar disorder and schizophrenia. GRID1 knockout mice show endophenotypes relevant for these pathologies and have been proposed as a model of schizophrenia and depression co-morbidity. GRID1 is widely expressed in the brain and largely predominates over GRID2 outside the cerebellum. GRID1 is localized at the postsynaptic density of excitatory synapses and its expression increases during postnatal development, consistent with a role of glutamatergic transmission in humans.

Fig.1 General structure of an ionotropic glutamate receptor subunit.

Application of GRID1 Membrane Protein in Literature

Benamer N., et al. GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons. Mol Psychiatry. 2018. 23(3): 691-700. PubMed ID: 28696429

The article provides insights into how GRID1 gene alterations can lead to dopaminergic dysfunctions in schizophrenia.
Gupta SC., et al. Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity. Neuropharmacology. 2015, 93: 274-84. PubMed ID: 25721396

Authors in this group demonstrate that GluD1 plays an essential role in dendritic spine development. GluD1 is highly required in normal spine development in the cortex and hippocampus.
Nenadic I., et al. Glutamate receptor δ 1 (GRID1) genetic variation and brain structure in schizophrenia. J Psychiatr Res. 2012, 46(12): 1531-9. PubMed ID: 23017809

The article demonstrates that GRID1 plays a potential role in thalamo-cortical functioning and is associated with schizophrenia.
Yadav R., et al. Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS One. 2012, 7(3): e32969. PubMed ID: 22412961

The article reveals that GRID1 gene is related to several neuropsychiatric disorders including schizophrenia, bipolar disorder, autism spectrum disorders, and major depressive disorder.
Guo S.Z., et al. A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population. Schizophr Res. 2007, 93(1-3): 385-90. PubMed ID: 17490860

This article reports that GRID1 gene is involved in the etiology of schizophrenia.

GRID1 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-GRID1 antibody development services.

As a leading service provider, Creative Biolabs is proud to present our professional service in membrane protein preparation and help you with the research of membrane proteins. Please do not hesitate to inquire us for more details.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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