To make go or no-go decisions at different stages of drug discovery and development, the quality,
sensitivity and accuracy of biomarkers are critical to help us make smart decisions. Creative
Biolabs is
dedicated to biomarker identification, assay development and validation services to provide our clients
with the key information that could help move your research forward.
Our Capabilities
Biomarker analysis and analytical readouts are critical in drug discovery and development, ranging from
target validation studies to lead optimization and candidate selection. Hence, the biomarker development to
measure the accuracy and sensitivity is necessary for making critical go or no-go decisions. With extensive
experience in biomarker identification, assay development and sample processing, Creative Biolabs can
support your drug discovery pipeline by providing biomarker development.
Fig.1 End-to-end solution for biomarker development.
Biomarker Identification
To identify specific biomarker for research, we focus on genetics/genomics services using state-of-the-art
technologies (such as sequencing, mass spectrometry and real time PCR) and equipment.
Analytical Services
We offer a broad range of specific analytical services using our platforms such as ELISA, EIA, Western
blotting, HPLC. For assays, we provide the following, but not limited to them.
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Determination
of Nitrite
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DA,
DOPAC, HVA
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CGRP
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C99,
C83, holoAPP
|
BDNF
|
Aβ1-40,
Aβ1-42
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Ach
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5HT
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EGF
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eNOS
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Eotaxin
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EPO
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F-kappaB
p65
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Fractalkine
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GAPDH
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G-CSF
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GLT-1
(GLAST)
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Glutamate
|
|
GM-CSF
|
GRO/KC
|
IDE
activity assay
|
IFN-γ
|
IGF-I
|
IL-1α,
IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12 (p70 or total), IL-13, IL-17A,
IL-18
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IP-10
|
KC/GRO/CINC
(CXCL1)
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LDH
Measurement
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Leptin
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LIX
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MCP-1
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|
MIP-1α,
MIP-2
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NA
|
PGE2
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Protein
Determination Assay
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P-ser9-GSK3β
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p-TAU,
total TAU
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RANTES
|
Synaptophysin
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TGF-β
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TNF-α
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VEGF
|
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Assay Development
Our senior scientists are committed to developing study-specific biomarker assays and analytical readouts
for animal models. We can transfer, develop and qualify results for you. Once the assay development is
completed, fast and accurate testing services can be implemented as soon as possible. The assays available include, but are not limited to the following:
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Bioanalytical
immunoassays
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Genetic
biomarkers
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Gene
expression testing
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Biobank
resource of flash frozen samples of our in vivo portfolio available
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Protein/phosphoprotein
analysis
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Plate-based
apoptosis assays
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Tumor
profiling for target expression and modulation
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Tumor
sampling for in vivo pre-clinical study to monitor for target modulation
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Cytokine
analysis
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Clinical
biochemistry testing
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Immunohistochemistry
capabilities
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Highlights
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Short turnaround time
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Comprehensive biomarker database
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Synergy between scientists across functional areas
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Rapid GLP validation of developed qualified assays
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Full solution provider from identification to assay design, measurement and analytical readouts.
Creative Biolabs offers strategic biomarker assay validation and qualification to help accurately test
your samples and provide you with reliable biological translations to make smart decisions in your drug
discovery. Whether the assays are performed at your facility or designed and implemented at Creative Biolabs, please feel free to contact us to tailor the best service for you.
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