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Magic™ Antibody Discovery - Feline FcRn (FCGRT & B2M) (24-297(FCGRT)&21-118(B2M)) Membrane Protein, Partial, -His -Avi tag&Tag Free, [Biotin] (CAT#: MP1451F)

Datasheet
This membrane protein is Feline FcRn (FCGRT & B2M) (24-297(FCGRT)&21-118(B2M)). It has been tested in SDS-PAGE, SPR. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Feline
  • Target Protein
  • FcRn (FCGRT & B2M)
  • Protein Length
  • ECD
  • Molecular Weight
  • Biotinylated Feline FCGRT&B2M Heterodimer Protein, His,Avitag (SPR verified), produced by co-expression of FCGRT and B2M, has a calculated MW of 34.0 kDa (FCGRT) and 11.5 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at the C-terminus, followed by an Avi tag and subunit Beta-2 microglobulin (B2M) contains no tag. The reducing (R) protein migrates as 36-40 kDa (FCGRT) and 18-20 kDa (B2M) respectively due to glycosylation.
  • Sequence
  • AA Ala 24 - Ser 297 (FCGRT) & Val 21 - Met 118 (B2M) (Accession # W5VRL5-1 (FCGRT) & Q5MGS7-1 (B2M)).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, SPR
  • Expression Systems
  • HEK293
  • Tag
  • Subunit FCGRT is fused with a His tag at the C-terminus, followed by an Avi tag and subunit B2M contains no tag
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • FcRn (FCGRT & B2M)
  • Full Name
  • Fc fragment of IgG receptor and transporter&beta-2-microglobulin
  • Introduction
  • This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • FCRN, alpha-chain, IgG receptor FcRn large subunit p51, Fc fragment of IgG, receptor, transporter, alpha, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, heavy chain of the major histocompatibility complex class I-like Fc receptor, immunoglobulin receptor, intestinal, heavy chain, major histocompatibility complex class I-like Fc receptor, neonatal Fc receptor, neonatal Fc-receptor for Ig, transmembrane alpha chain of the neonatal receptor

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