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Magic™ Antibody Discovery - Human IL-6 R alpha / CD126 (20-365) Membrane Protein, Partial, -His tag (CAT#: MP0297F)

Datasheet
This membrane protein is Human IL-6 R alpha / CD126 (20-365). It has been tested in SDS-PAGE, ELISA. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • IL-6 R alpha / CD126
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 39.4 kDa. The protein migrates as 55-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • Sequence
  • AA Leu 20 - Pro 365 (Accession # NP_000556.1).

Product Description

  • Activity
  • Yes
  • Application
  • SDS-PAGE, ELISA
  • Expression Systems
  • HEK293
  • Tag
  • His tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >92% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • IL-6 R alpha / CD126
  • Full Name
  • interleukin 6 receptor
  • Introduction
  • This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9.
  • Alternative Names
  • IL6Q; gp80; CD126; HIES5; IL6RA; IL6RQ; IL-6RA; IL6QTL; IL-6R-1; interleukin-6 receptor subunit alpha; CD126 antigen; IL-6 receptor subunit alpha; membrane glycoprotein 80

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