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Magic™ Antibody Discovery - Human SMAC / Diablo (56-239) Membrane Protein, Partial, -His tag (CAT#: MP0838F)

Datasheet
This membrane protein is Human SMAC / Diablo (44-197). It has been tested in SDS-PAGE. We provide this protein to facilitate your membrane protein antibody discovery and development.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SMAC / Diablo
  • Protein Length
  • ECD
  • Molecular Weight
  • The protein has a calculated MW of 21.7 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).
  • Sequence
  • AA Ala 56 - Asp 239 (Accession # NP_063940)

Product Description

  • Application
  • SDS-PAGE
  • Expression Systems
  • E.coli
  • Tag
  • His Tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Please see Certificate of Analysis for specific instructions.
  • Endotoxin
  • <1.0 EU/μg by the LAL method
  • Purity
  • >95% as determined by SDS-PAGE.
  • Buffer
  • Lyophilized from 0.22 μm filtered solution in 20 mM HEPES, 150 mM NaCl, pH7.5. Normally trehalose is added as protectant before lyophilization.

Target

  • Target Protein
  • SMAC / Diablo
  • Full Name
  • diablo IAP-binding mitochondrial protein
  • Introduction
  • This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Alternative Names
  • SMAC; DFNA64; diablo homolog, mitochondrial; diablo-like protein; direct IAP-binding protein with low pI; second mitochondria-derived activator of caspase

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