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Magic™ Membrane Protein Human COQ6 (Coenzyme Q6, monooxygenase) Full Length (CAT#: MPC4471K) Made to Order

Datasheet
This product is a made-to-order Human COQ6 membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • COQ6
  • Protein Length
  • Full length
  • Protein Class
  • Oxidoreductase
  • Sequence
  • MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAM
    ACALGYDIHFHDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSS
    FGAWDHICNMRYRAFRRMQVWDACSEALIMFDKDNLDDMGYIVENDVIMH
    ALTKQLEAVSDRVTVLYRSKAIRYTWPCPFPMADSSPWVHITLGDGSTFQ
    TKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSEATENNVAWQR
    FLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSD
    ADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGL
    GHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNG
    KDLGSVSHLTGYETERQRHNTALLAATDLLKRLYSTSASPLVLLRTWGLQ
    ATNAVSPLKEQIMAFASK

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • COQ6
  • Full Name
  • Coenzyme Q6, monooxygenase
  • Introduction
  • The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
  • Alternative Names
  • COQ6; CGI10; CGI-10; COQ10D6; ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; coenzyme Q10 monooxygenase 6; coenzyme Q6 homolog, monooxygenase; Coenzyme Q6, monooxygenase

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