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Magic™ Membrane Protein Human GABRA4 (Gamma-aminobutyric acid type A receptor subunit alpha4) Expressed in E.coli with 6xHis and SUMO tag at the N-terminus for Antibody Discovery, Partial (36-258aa) (CAT#: MPX4650K)

Datasheet
This product is a 41.8kDa Human GABRA4 membrane protein expressed in E.coli. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • GABRA4
  • Protein Length
  • Partial (36-258aa)
  • Protein Class
  • Transporter; Ion channel
  • Molecular Weight
  • 41.8kDa
  • TMD
  • 4
  • Sequence
  • QNQKEEKLCTENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGY

Product Description

  • Expression Systems
  • E.coli
  • Tag
  • 6xHis and SUMO tag at the N-terminus
  • Protein Format
  • Soluble
  • Purity
  • >90% as determined by SDS-PAGE
  • Buffer
  • Tris-based buffer, 50% glycerol

Target

  • Target Protein
  • GABRA4
  • Full Name
  • Gamma-aminobutyric acid type A receptor subunit alpha4
  • Introduction
  • Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.
  • Alternative Names
  • Gamma-aminobutyric acid receptor subunit alpha-4; GABA(A) receptor, alpha 4; gamma-aminobutyric acid (GABA) A receptor, alpha 4; gamma-aminobutyric acid A receptor alpha 4; gamma-aminobutyric acid type A receptor alpha4 subunit; GABRA4; Gamma-aminobutyric acid type A receptor subunit alpha4

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