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Magic™ Membrane Protein Human SLAMF6 (SLAM family member 6) Expressed in NS0 for Antibody Discovery, Partial (28-225aa) (CAT#: MPX0350K)

Datasheet
This product is a 48.9 kDa Human SLAMF6 membrane protein expressed in NS0. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • SLAMF6
  • Protein Length
  • Partial (28-225aa)
  • Protein Class
  • Receptor; Immunity
  • Molecular Weight
  • 48.9 kDa
  • TMD
  • 1
  • Sequence
  • LMVNGILGESVTLPLEFPAGEKV
    NFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLK
    MEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELH
    LTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENA
    VSNLSFSVSAQKLCEDVKIQYTDTK

Product Description

  • Expression Systems
  • NS0
  • Tag
  • hIgG1 Fc tag at the C-terminus
  • Protein Format
  • Soluble
  • Reconstitution
  • Reconstitute at 100 μg/mL in sterile PBS.
  • Endotoxin
  • <0.01 EU per 1 μg of the protein by the LAL method.
  • Purity
  • >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
  • Buffer
  • Lyophilized from a 0.2 μm filtered solution in PBS.

Target

  • Target Protein
  • SLAMF6
  • Full Name
  • SLAM family member 6
  • Introduction
  • The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
  • Alternative Names
  • SLAMF6; KALI; NTBA; CD352; KALIb; Ly108; NTB-A; SF2000; NK-T-B-antigen; NTBA receptor; activating NK receptor; natural killer-, T- and B-cell antigen; SLAM family member 6

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