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NativeExtract™ Human TLR2 Membrane Protein (Full length, Super Nanodisc) (CAT#: S01YF-1023-KX464)

Datasheet
This product is recombinant Human TLR2 protein in native nanodisc form. The synthetic compound we developed can solubilize the TLR2 protein from membrane while retaining the native structure.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • TLR2
  • Protein Length
  • Full length
  • Molecular Weight
  • 89.8 kDa

Product Description

  • Activity
  • Yes
  • Application
  • ELISA; SPR Binding Assays; Phage Display Screening; Immunity; Functional Assays
  • Expression Systems
  • HEK293 expression system
  • Tag
  • Flag tag at the C-terminus
  • Protein Format
  • Native Nanodisc
  • Buffer
  • 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Target

  • Target Protein
  • TLR2
  • Full Name
  • Toll like receptor 2
  • Introduction
  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • TLR2; TIL4; CD282; toll-like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll like receptor 2

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