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Magic™ Membrane Protein Human NAGPA (N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase) Full Length (CAT#: MPC4080K) Made to Order

Datasheet
This product is a made-to-order Human NAGPA membrane protein expressed in HEK293. The protein is for research use only and is not approved for use in humans or in clinical diagnosis.

Product Specifications

  • Host Species
  • Human
  • Target Protein
  • NAGPA
  • Protein Length
  • Full length
  • Protein Class
  • Receptor
  • TMD
  • 1
  • Sequence
  • MATSTGRWLLLRLALFGFLWEASGGLDSGASRDDDLLLPYPRARARLPRD
    CTRVRAGNREHESWPPPPATPGAGGLAVRTFVSHFRDRAVAGHLTRAVEP
    LRTFSVLEPGGPGGCAARRRATVEETARAADCRVAQNGGFFRMNSGECLG
    NVVSDERRVSSSGGLQNAQFGIRRDGTLVTGYLSEEEVLDTENPFVQLLS
    GVVWLIRNGSIYINESQATECDETQETGSFSKFVNVISARTAIGHDRKGQ
    LVLFHADGQTEQRGINLWEMAEFLLKQDVVNAINLDGGGSATFVLNGTLA
    SYPSDHCQDNMWRCPRQVSTVVCVHEPRCQPPDCHGHGTCVDGHCQCTGH
    FWRGPGCDELDCGPSNCSQHGLCTETGCRCDAGWTGSNCSEECPLGWHGP
    GCQRPCKCEHHCPCDPKTGNCSVSRVKQCLQPPEATLRAGELSFFTRTAW
    LALTLALAFLLLISTAANLSLLLSRAERNRRLHGDYAYHPLQEMNGEPLA
    AEKEQPGGAHNPFKD

Product Description

  • Expression Systems
  • HEK293
  • Tag
  • Flag-StrepII or based on specific requirements
  • Protein Format
  • Detergent or based on specific requirements (Detergent, Liposome, Nanodisc, SMALPs, VLP)

Target

  • Target Protein
  • NAGPA
  • Full Name
  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
  • Introduction
  • Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. The encoded preproprotein is proteolytically processed by furin to generate the mature enzyme, a homotetramer of two disulfide-linked homodimers. Mutations in this gene are associated with developmental stuttering in human patients.
  • Alternative Names
  • NAGPA; UCE; APAA; alpha-N-acetylglucosaminyl phosphodiesterase; lysosomal alpha-N-acetylglucosaminidase; mannose 6-phosphate-uncovering enzyme; phosphodiester alpha-GlcNAcase; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

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