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Norovirus GII.4 Virus-like Particles (NoV GII.4 VLPs) (CAT#: VLP-021YF)

Datasheet
Recombinant Norovirus GII.4 Virus-like Particles (NoV GII.4 VLPs) are produced in Insect cell expression system, assembled with VP1 structure protein. VLP is mimicking the native 3D structure of viruses which can elicit strong immune responses. However, VLPs lack viral genomic material which makes them non-infectious, unable to replicate and enhance the safety during manufacture and administration. NoV GII.4 VLPs can be used in the development of NoV GII.4 diagnostics and in vaccine development and R&D (including use as an immunogen).

Product Specifications

  • Structural Proteins
  • VP1
  • Expression Systems
  • HEK293 expression system
  • Purity
  • >70%
  • Buffer
  • PBS pH7.4
  • Form
  • Liquid
  • Alternative Names
  • Norovirus GII.4 Virus-like Particles; NoV GII.4 VLPs; Norovirus GII.4 Virus; NoV GII.4; VLP; Virus-like particle
  • Storage
  • Store at -80 °C long term. Avoid repeated freeze/thaw cycles.

Virus Background

  • Virus Family
  • Calciviridae
  • Virus Species
  • Norovirus GII.4 Virus
  • Virus Overview
  • Norovirus, also known as NoV, is in the Caliciviridae family. It's non-enveloped, positive-sense, single-stranded RNA virus. Noroviruses can genetically be classified into at least seven different genogroups (GI, GII, GIII, GIV, GV, GVI, and GVII), which can be further divided into different genetic clusters or genotypes. Most noroviruses that infect humans belong to genogroups GI and GII. The variant GII.4 has been identified as the most common cause of Norovirus outbreaks since 2002. The norovirus genome encodes a large polyprotein which is cleaved into six smaller non-structural proteins (NS1/2 to NS7) by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2).
    It's a very contagious virus that causes gastroenteritis. People of all ages can get infected and sick with norovirus. The symptoms of norovirus infection include nausea, vomiting, stomach pain or cramps, watery or loose diarrhea, feeling ill, low-grade fever, muscle pain. Most noroviruses that infect humans belong to genogroups GI and GII.
    The NoV infection can be confirmed by laboratory testing such as virus isolation, RT-PCR, and serology.
  • Virus Structure
  • Non-enveloped, positive-sense, single-stranded RNA virus
  • Related Disease
  • Gastroenteritis

Customer reviews and Q&As    

Customer Review

Induced a strong immune response

Mice receiving NoV GII.4 VLP produced a strong immune response.
2022-12-20

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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