S1PR2 Membrane Protein Introduction

Introduction of S1PR2

Sphingosine 1-phoshate 2 (S1PR2) is encoded by the S1PR2 gene. It belongs to the G-protein-coupled receptor (GPCR) family which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Edg5 transduced S1P-evoked signaling events relevant to cell proliferation and survival, including activation of the ERK/MAP kinases, and immediate-early induction of c-Jun and c-Fos.

Basic Information of S1PR2
Protein Name	Sphingosine 1-phoshate 2
Gene Name	S1PR2, EDG5
Aliases	S1P receptor 2, S1P receptor Edg-5
Organism	Homo sapiens (Human)
UniProt ID	O95136
Transmembrane Times	7
Length (aa)	353
Sequence	MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFL GNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDK SCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCV VRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPV IYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV

Function of S1PR2 Membrane Protein

S1PR2 is a receptor for the lysosphingolipid S1P. S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, it is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. Research has demonstrated that deficiency in S1PR2 enhanced bacterial clearance and promoted survival in the mouse model of sepsis. These beneficial effects are due to an improvement in the phagocytic activity of S1PR2-deficient macrophages. Therefore, interventions targeting S1PR2 signaling may offer a promising therapeutic approach for the prevention and/or treatment of sepsis.

Fig.1 Proposed mechanism involved in impaired bacterial clearance mediated by S1PR2 signaling in macrophage.

Application of S1PR2 Membrane Protein in Literature

An s., et al. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. Biol Chem. 2000, 275(1): 288-96. PubMed ID: 10617617

This article accounts for, at least in part, S1P-induced cell proliferation, survival, and related signaling events.
Zheng Z., et al. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. Biol Chem. 1999, 274(39): 27351-8. PubMed ID: 10488065

This article reveals that Edg-5 communicate not only with G(i) but also with G(q) and G(13). These studies represent the first characterization of S1P receptor activity through G proteins directly and establish fundamental differences in coupling.
Santos-cortez R.L., et al. Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. Am J Hum Genet. 2016, 98(2): 331-8. PubMed ID: 26805784

This article suggests the possibility of developing therapies against hair cell damage (e.g., from ototoxic drugs) through targeted stimulation of S1PR2.
Sanchez T., et al. Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. Arterioscler Thromb Vasc Biol. 2007, 27(6): 1312-8. PubMed ID: 17431187

This article reveals that S1P2R activation in endothelial cells increased vascular permeability. The balance of S1P1 and S1P2 receptors in the endothelium may determine the regulation of vascular permeability by S1P.
Malchinkhuu E., et al. S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways inde -pendent of PTEN. Biochem biophys res commun. 2008, 366(4): 963-8. PubMed ID: 18088600

Authors in this group characterized the signaling mechanisms involved in the inhibitory action by S1P.

S1PR2 Preparation Options

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