Naïve sdAb Library Construction Service
As a leading CRO company, Creative Biolabs has been armed with a robust and standardized sdAb development platform to offer the naïve sdAb library for our global customers. Creative Biolabs also has hugely experienced specialists working alongside our technology teams to provide an enormous breadth of expert advice and technical support to meet our customers' specific demands.
Naïve sdAb Library at Creative Biolabs
When toxic or nonimmunogenic antigens are potentially used as immunogens, or immunization is not available for some other reasons, a large naïve sdAb library could be employed as an alternative approach. High-quality naïve library is shown to be highly efficient in the generation of specific sdAbs against different types of antigens. Custom naïve sdAb library at Creative Biolabs is designed to give you the best tools and worldwide supports to meet the challenges you face in the sdAb development, ensuring your purpose and meeting the required levels. Our naïve sdAb library is unique in which the sdAb gene repertoire used is generally comprised of antibody fragments from a source of natural, unimmunized, and healthy individuals; as such, they are useful for selecting sdAbs against a wide variety of antigens.
Fig.1 Naïve sdAb library.
Advantage of Naïve sdAb Library
The specificity of our naïve sdAb library is that it is a one-pot collection, unspecific randomness, and no preferred antigen, resulting in the explicitly unbiased nature of the sdAb repertoires. It is necessary to create a large naïve sdAb library in terms of amplifying the library diversity and antigenic epitope coverage, increasing the chance of identifying sdAbs for any given antigen. This approach allows for the identification of a wider diversity of binders for any potential antigens and saves time and costs related to preparing a new library for any new antigens of interest. Despite the lack of somatic maturation stimulated in vivo by the immunization process, the use of our large naïve sdAb library with the greatest genetic diversity allows for the identification of sdAbs with high specificity and affinity in the nanomolar or picomolar range.
Creative Biolabs has made a long-term commitment to the discovery and development of sdAbs. To bring our customers impeccable service of sdAb discovery, our seasoned scientific team has developed a robust library construction platform to offer the best and convenient sdAb related services. We focus on developing the best quality naïve sdAb library to help you to retrieve practical sdAbs against virtually any target. To get more information, a quote, or to schedule a teleconference, please contact us.
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We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.
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