Synthetic sdAb Library Construction Service
Creative Biolabs possesses unchallenged experience in synthetic sdAb library generation. As a global leader of sdAb discovery and manufacturing, we have been committed to offering customers an impeccable sdAb library based on brilliant technical scientists, advanced techniques, and a reliable and robust construction system. We work closely with our customers so as to design every project according to their individual requirements.
Synthetic sdAb Library at Creative Biolabs
The synthetic sdAb library has higher diversity and utility and is a promising path toward obtaining practical sdAbs against any specific target, especially when it is challenging to immunize or when sdAbs are required against a specific epitope of the antigen. With the scientific expertise of our staff and experience in designing and conducting a custom service, Creative Biolabs will build synthetic libraries with the introduction of diversity, improved library quality, and downstream characteristics of sdAbs by control over the genetic makeup of genes for functionality before library construction. In addition, a semi-synthetic library construction that combined natural and synthetic diversity is also provided at Creative Biolabs; it is often created to increase natural diversity while maintaining a certain level of functional diversity. Our high-quality synthetic and semi-synthetic sdAb library will be enough to obtain the high-affinity binders against a wide variety of antigens to meet our customers' individual requirements.
Advantage of Synthetic sdAb Library
Limited size and diversity are vital concerns affecting the efficiency of sdAb screening from large-size naïve libraries. However, synthetic libraries are already to obtain a repertoire of over 109 individual clones, which covers all possible amino acid combinations to improve the diversity and size of the library. The randomization within the CDR regions leads to libraries with a higher proportion of potentially functional binders so that the selection of antigen binders and the affinity improvement of the selected binder for a particular antigen should be more successful.
More importantly, these libraries, in association with high-throughput screening, deliver panels with thousands of sdAbs that bind distinct epitopes on the same target antigen; sdAb with the highest potencies can be then identified. If sufficiently large and diverse, this type of library is a source of antibodies against a large number of different antigens, including self, nonimmunogenic and toxic antigens; and for this reason, synthetic sdAb libraries are now extensively used in the industry.
Large synthetic sdAb libraries have been proved to be a suitable source to retrieve potent antigen-binders avoiding the immunization procedure. Based on the most advanced techniques and years of experience in the sdAb field, Creative Biolabs offers custom synthetic sdAb library services for your scientific research or therapeutic and diagnostic applications. Just feel free to contact us if you have additional questions about our services or would like to consult with the experts at Creative Biolabs.
Case Study
We are offering highly customized CRO services to assist your Single Domain Antibody (sdAb) related projects. Please Contact Us for more details.
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