SLC27A6 Membrane Protein Introduction

Introduction of SLC27A6

SLC27A6 is encoded by FATP6 or SLC27A6 gene and is also known as Long-chain fatty acid transport protein 6 (FATP6), Fatty acid transport protein 6, Fatty-acid-coenzyme A ligase, very long-chain 2, Solute carrier family 27 member 6 (SLC27A6), Very long-chain acyl-CoA synthetase homolog 1 (VLCSH1, hVLCS-H1). It belongs to FATP family, also known as solute carrier family 27, which contains members A1 through 6 (SLC27A1-6) family. SLC27A6 is reported to be involved in the uptake and metabolism of long chain fatty acids.

Function of SLC27A6 Membrane Protein

SLC27A6 has been shown to function as a fatty acid transporter in the heart by increasing long chain fatty acids (LCFA) uptake and metabolism, which are critical to many physiological and cellular processes. SLC27A6 is involved in the translocation of long-chain fatty acids across the plasma membrane and is thought to function as the predominant FATP in the heart. SLC27A6 is encoded by the SLC27A6 gene and expressed primarily in the heart, specifically in the sarcolemma of cardiomyocytes and plasma membranes juxtaposed to the blood vessels of the heart, where it colocalizes with another fatty acid transport protein, CD36. SLC27A6 has been shown to function as a fatty acid transporter in the heart by increasing LCFA uptake. Given these findings, SLC27A6 has been speculated to play a role in lipid-related cardiac disorders. Rats that underwent cardiac infarction had reduced SLC27A6 protein, as well as FATP1, accompanied by reduced fatty acid oxidation and lipid incorporation. However, the precise role of SLC27A6 in the heart and other tissues remains to be determined, as animal models targeting SLC27A6 have not been generated.

Fig.1 Proposed SLC27A6 signaling pathway in the cellular uptake of free fatty acids.

Application of SLC27A6 Membrane Protein in Literature

1. Saini-Chohan H.K., et al. Delineating the role of alterations in lipid metabolism to the pathogenesis of inherited skeletal and cardiac muscle disorders: Thematic Review Series: Genetics of Human Lipid Diseases. J. Lipid Res. 2012, 53(1):4-27. PubMed ID: 22065858
   
   

   This article indicates that transport of fatty acids is facilitated by several classes of specific transporters expressed on the cell membrane. These specific transporters include fatty acid transport proteins 1-6 (FATP1-6), fatty acid translocase/CD36 (FAT/CD36), fatty acid binding proteins (FABP), plasma membrane fatty acid binding protein (FABPpm), cytosolic fatty acid binding proteins (FABPc) and caveolin.

2. Anderson C.M., et al. SLC27 fatty acid transport proteins. Molecular aspects of medicine. 2013, 34(2-3):516-528. PubMed ID: 23506886
   
   

   This article reveals that SLC27A6 has been shown to function as a fatty acid transporter in the heart by increasing long chain fatty acids (LCFA) uptake and SLC27A6 has been speculated to play a role in lipid-related cardiac disorders.

3. Auinger, A., et al. A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy. British Journal of Nutrition. 2012, 107 (10), 1422-1428. PubMed ID: 21920065
   
   

   This article reports that the effects of the SLC27A6 polymorphism on TAG are mediated by affluent dietary fat. The SLC27A6-7T>A polymorphism may protect from traits of the metabolic syndrome and CVD.

4. Díaz P., et al. Increased placental fatty acid transporter 6 and binding protein 3 expression and fetal liver lipid accumulation in a mouse model of obesity in pregnancy. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2015, 309(12):R1569-R1577. PubMed ID: 26491104
   
   

   This article reports that the expression of SLC27A6 is elevated in the placental barrier of obese dams for the first time, suggesting that increased placental lipid transfer capacity could contribute to fetal overgrowth and greater lipid accumulation in the fetal liver.

5. Bionaz M., et al. ACSL1, AGPAT6, FABP3, LPIN1, and SLC27A6 Are the Most Abundant Isoforms in Bovine Mammary Tissue and Their Expression Is Affected by Stage of Lactation. The Journal of Nutrition. 2008, 138(6):1019-1024. PubMed ID: 18492828
   
   

   The results of this article suggest that SLC27A6, ACSL1, FABP3, AGPAT6, and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.

SLC27A6 Preparation Options

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