SLC2A11 Membrane Protein Introduction

Introduction of SLC2A11

Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11), also known as Glucose transporter type 10 (GLUT-10) or Glucose transporter type 11 (GLUT-11), is a protein that in humans is encoded by the SLC2A11 gene. It belongs to the family of plasma membrane proteins that mediate the transport of sugars across the membrane by facilitative diffusion.

Basic Information of SLC2A11
Protein Name	Solute carrier family 2, facilitated glucose transporter member 11
Gene Name	SLC2A11
Aliases	Glucose transporter type 10, GLUT-10, Glucose transporter type 11, GLUT-11
Organism	Homo sapiens (Human)
UniProt ID	Q9BYW1
Transmembrane Times	12
Length (aa)	503
Sequence	MEDELEPSLRPRTQIQGRILLLTICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSCVVIERVGRRVLLIGGYSLMTCWGSIFTVALCLQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIMEALSHFLYVPFLGVCVCGAIYTGLFLPETKGKTFQEISKELHRLNFPRRAQGPTWRSLEVIQSTEL

Function of SLC2A11 Membrane Protein

As a member of the plasma membrane proteins family, SLC2A11 (GLUT11) consists of three variants (GLUT11-A, GLUT11-B, and GLUT11-C) which have been identified that only differ in their N-terminal sequences. Studies have shown that the three isoforms are expressed in a tissue-specific manner: GLUT11-A is present in heart, skeletal muscle, and kidney; GLUT11-B is expressed in placenta, adipose tissue, and kidney; and GLUT11-C is found in adipose tissue, heart, skeletal muscle, and pancreas. During the past years, glucose transport activity for GLUT11 was detected in liposomes reconstituted with GLUT11 containing membranes. Also, GLUT11 could transport fructose but not galactose and shows a rather low affinity for cytochalasin B. What’s more, human GLUT11 is expressed exclusively in slow-twitch muscle fibers and is unaffected by physiological and pathophysiological conditions except in primary myopathy.

Fig.1 Structure of glucose transporter.

Application SLC2A11 of Membrane Protein in Literature

Scheepers A., et al. Characterization of the human SLC2A11 (GLUT11) gene: alternative promoter usage, function, expression, and subcellular distribution of three isoforms, and lack of mouse orthologue. Molecular membrane biology. 2005, 22(4):339-51. PubMed ID: 16154905

This article suggests that different promoters and splicing of the human SLC2A11 gene generate three GLUT11 isoforms which are expressed in a tissue-specific manner but do not appear to differ in their functional characteristics.
Gaster M., et al. GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fiber type-specific pattern. Pflügers Archiv. 2004, 448(1):105-13. PubMed ID: 14704796

This report aims to investigate the pattern of expression and localization of the GLUT isoforms 8, 11 and 12 in human skeletal muscle using an immunohistochemical approach. It suggests that GLUT11 immunoreactivity is expressed exclusively in slow-twitch muscle fibers and is unaffected by physiological and pathophysiological conditions except in primary myopathy.
Sasaki T., et al. Molecular cloning of a member of the facilitative glucose transporter gene family GLUT11 (SLC2A11) and identification of transcription variants. Biochemical and biophysical research communications. 2001, 289(5):1218-24. PubMed ID: 11741323

This article suggests that transcription of GLUT11/SCL2A11 gene is controlled in a complex manner.
DOEGE H., et al. Characterization of human glucose transporter (GLUT) 11 (encoded by SLC2A11), a novel sugar-transport facilitator specifically expressed in heart and skeletal muscle. Biochemical Journal. 2001, 359(2):443-9.

This report indicates that GLUT11 is a novel, muscle-specific transport facilitator that is a member of the extended GLUT family of sugar/polyol transport facilitators.

SLC2A11 Preparation Options

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