SLC2A12 Membrane Protein Introduction

Introduction of SLC2A12

Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12), also known as glucose transporter type 12 or GLUT-12, is a protein that in humans is encoded by the SLC2A12 gene. It belongs to the class III hexose transporter family which is distinguished based on primary sequence comparisons.

Basic Information of SLC2A12
Protein Name	Solute carrier family 2, facilitated glucose transporter member 12
Gene Name	SLC2A12
Aliases	Glucose transporter type 12, GLUT-12
Organism	Homo sapiens (Human)
UniProt ID	Q8TD20
Transmembrane Times	12
Length (aa)	617
Sequence	MVPVENTEGPSLLNQKGTAVETEGSGSRHPPWARGCGMFTFLSSVTAAVSGLLVGYELGIISGALLQIKTLLALSCHEQEMVVSSLVIGALLASLTGGVLIDRYGRRTAIILSSCLLGLGSLVLILSLSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILSAYISNYAFANVFHGWKYMFGLVIPLGVLQAIAMYFLPPSPRFLVMKGQEGAASKVLGRLRALSDTTEELTVIKSSLKDEYQYSFWDLFRSKDNMRTRIMIGLTLVFFVQITGQPNILFYASTVLKSVGFQSNEAASLASTGVGVVKVISTIPATLLVDHVGSKTFLCIGSSVMAASLVTMGIVNLNIHMNFTHICRSHNSINQSLDESVIYGPGNLSTNNNTLRDHFKGISSHSRSSLMPLRNDVDKRGETTSASLLNAGLSHTEYQIVTDPGDVPAFLKWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTVTDLIGLPWVCFIYTIMSLASLLFVVMFIPETKGCSLEQISMELAKVNYVKNNICFMSHHQEELVPKQPQKRKPQEQLLECNKLCGRGQSRQLSPET

Function of SLC2A12 Membrane Protein

GLUT12 (SLC2A12) is a member of the class III hexose transporter family, which contains dileucine motifs- both at the N- and C-terminal end of the protein. The sequence of SLC2A12 presents all the characteristics of the GLUT family, in particular, the 12 putative trans-membrane domains required for function as a glucose transporter. It exhibits 40% amino acid homology with GLUT10 and 29% with GLUT4. The expression of SLC2A12 has been found in numerous tissues, including skeletal muscle, adipose tissue, small intestine, heart, placenta, and in the pregnant and lactating mammary gland, as well as in cancerous tissue of breast and prostate and widely expressed in the fetus. Studies have shown that SLC2A12 facilitates transport of glucose with an apparent preferential substrate affinity for glucose over the other hexoses studied, supporting the hypothesis that SLC2A12 acts to facilitate glucose transport in vivo in many different cells where it is expressed.

Fig.1 Schematic representation of the structure of the SLC2A glucose transporters. (Govers, 2014)

Application SLC2A12 of Membrane Protein in Literature

White M.A., et al. GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocrine-related cancer. 2018, 25(4):453-469. PubMed ID: 29431615

This article demonstrates that prostate cancer cells can increase the functional levels of GLUT12 through multiple mechanisms to promote glucose uptake and subsequent cell growth.
Matsui C., et al. Potential roles of GLUT12 for glucose sensing and cellular migration in MCF-7 human breast cancer cells under high glucose conditions. Anticancer research. 2017, 37(12):6715-22. PubMed ID: 29187448

This study investigates glucose sensing and mediation, which are responsible for the high motility of MCF-7 cells. It suggests that GLUT12 plays a critical role in the model of breast cancer progression through high glucose concentrations.
Gude N.M., et al. Expression of GLUT12 in the fetal membranes of the human placenta. Placenta. 2005, 26(1):67-72. PubMed ID: 15664413

The study aims to characterize the expression of the novel glucose transporter GLUT12 in the fetal membranes of the human placenta. Results show that GLUT12 is expressed in cells of human fetal membranes and suggest that GLUT12 may play a role in the facilitation of glucose transport into these cells.
Pujol-Giménez J., et al. Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods. American Journal of Physiology-Cell Physiology. 2015, 308(12):C1008-22. PubMed ID: 25855082

The goal of this study is to characterize the functional properties of GLUT12 by radiotracer and electrophysiological methods. Data obtained from the results indicate that GLUT12 may have a specific physiological role in glucose homeostasis, which needs to be discovered.
Pujol-Gimenez J., et al. Expression of the glucose transporter GLUT12 in Alzheimer's disease patients. Journal of Alzheimer's Disease. 2014, 42(1):97-101. PubMed ID: 24820014

This article aims to investigate the expression of GLUT12 in frontal cortex from Alzheimer's disease patients. Results suggest that the expression level of GLUT12 is significantly higher in the AD when compared to aged controls.

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Reference

Govers R. (2014). Cellular regulation of glucose uptake by glucose transporter GLUT4. Advances in clinical chemistry. 66: 173-240.

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