SLC2A2 Membrane Protein Introduction

Introduction of SLC2A2

Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2), also known as Glucose transporter type 2, liver (GLUT-2), is a protein that in humans is encoded by the SLC2A2 gene. It is the principal transporter for transfer of glucose between liver and blood that enables protein facilitated glucose movement across cell membranes. In addition to transfer glucose, it is also capable of transporting fructose.

Basic Information of SLC2A2
Protein Name	Solute carrier family 2, facilitated glucose transporter member 2
Gene Name	SLC2A2
Aliases	Glucose transporter type 2, GLUT-2
Organism	Homo sapiens (Human)
UniProt ID	P11168
Transmembrane Times	12
Length (aa)	524
Sequence	MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV

Function of SLC2A2 Membrane Protein

GLUT2 (SLC2A2), a member of the GLUTs family, is a low-affinity, high capacity transporter. It has been reported that SLC2A2 mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells. In addition to transport glucose, it also transports galactose, D-mannose, and D-fructose. Recently, SLC2A2 was shown to transport glucosamine with high affinity. What’s more, SLC2A2 may also participate in the release of absorbed or reabsorbed glucose into the bloodstream at the basolateral membrane of the respective epithelial cells in the small intestine and kidney. In the past years, the consequences of SLC2A2 deficiency have been analyzed in detail for the various tissues, where SLC2A2 is involved and/or essential in maintaining whole-body glucose homeostasis.

Fig.1 Functional β-cells respond to increase glucose levels by increasing insulin secretion. (Pagliuca, 2013)

Application SLC2A2 of Membrane Protein in Literature

Ono E., et al. Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment. PloS one. 2018, 13(4):e0195960. PubMed ID: 29677207

This article finds that the glucose transporter GLUT2 is highly expressed in the lumen of sweat glands from atopic dermatitis (AD) patients. AD patients with chronic inflammation have significantly increased GLUT2 mRNA expression and near normal sweat glucose levels. It indicates that the increased glucose levels might be affected by AD severity and phenotype.
Li B., et al. Inhibition of Glucose Transport by Tomatoside A, a Tomato Seed Steroidal Saponin, through the Suppression of GLUT2 Expression in Caco-2 Cells. Journal of agricultural and food chemistry. 2018, 66(6):1428-34. PubMed ID: 29355315

This article demonstrates for the first time that the nontransportable tomato seed steroidal saponin, tomatoside A, suppress GLUT2 expression via PKC signaling pathway during the ASBT-influx/MRP2-efflux process in Caco-2 cells.
Kim Y.H., et al. SLC2A2 (GLUT2) as a novel prognostic factor for hepatocellular carcinoma. Oncotarget. 2017, 8(40):68381. PubMed ID: 28978124

This report finds that SLC2A2 is associated with clinical stages and independently associated with overall survival in patients with hepatocellular carcinoma (HCC). It indicates that SLC2A2 may be used as a new prognostic factor for HCC.
Amalan V., et al. Antidiabetic and antihyperlipidemic activity of p-coumaric acid in diabetic rats, role of pancreatic GLUT 2: In vivo approach. Biomedicine & Pharmacotherapy. 2016, 84:230-6. PubMed ID: 27662473

This article suggests that p-CA modulates glucose and lipid metabolism via GLUT 2 activation in the pancreatic and has potentially beneficial effects in improving or treating metabolic disorders.
Kim H.S., et al. Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression. Biochemical and biophysical research communications. 2008, 367(3):623-9. PubMed ID: 18191635

This report suggests that RGZ could stimulate the release and synthesis of insulin through the upregulation of GLUT-2, GCK, and BETA2/NeuroD gene expression.

SLC2A2 Preparation Options

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Reference

Pagliuca, et al. (2013). How to make a functional β-cell. Development. 140(12): 2472-2483.

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