SLC2A6 Membrane Protein Introduction

Introduction of SLC2A6

Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6), also known as Glucose transporter type 6 (GLUT-6) or Glucose transporter type 9 (GLUT-9), is a protein that in humans is encoded by the SLC2A6 gene. As a protein associated with the process of hexose transporting into mammalian cells, it contains 12 transmembrane domains and a number of critical conserved residues.

Basic Information of SLC2A6
Protein Name	Solute carrier family 2, facilitated glucose transporter member 6
Gene Name	SLC2A6
Aliases	Glucose transporter type 6, GLUT-6, Glucose transporter type 9, GLUT-9
Organism	Homo sapiens (Human)
UniProt ID	Q9UGQ3
Transmembrane Times	12
Length (aa)	507
Sequence	MQEPLLGAEGPDYDTFPEKPPPSPGDRARVGTLQNKRVFLATFAAVLGNFSFGYALVYTSPVIPALERSLDPDLHLTKSQASWFGSVFTLGAAAGGLSAMILNDLLGRKLSIMFSAVPSAAGYALMAGAHGLWMLLLGRTLTGFAGGLTAACIPVYVSEIAPPGVRGALGATPQLMAVFGSLSLYALGLLLPWRWLAVAGEAPVLIMILLLSFMPNSPRFLLSRGRDEEALRALAWLRGTDVDVHWEFEQIQDNVRRQSSRVSWAEARAPHVCRPITVALLMRLLQQLTGITPILVYLQSIFDSTAVLLPPKDDAAIVGAVRLLSVLIAALTMDLAGRKVLLFVSAAIMFAANLTLGLYIHFGPRPLSPNSTAGLESESWGDLAQPLAAPAGYLTLVPLLATMLFIMGYAVGWGPITWLLMSEVLPLRARGVASGLCVLASWLTAFVLTKSFLPVVSTFGLQVPFFFFAAICLVSLVFTGCCVPETKGRSLEQIESFFRTGRRSFLR

Function of SLC2A6 Membrane Protein

GLUT6 (SLC2A6) was first discovered in 2000 when searching the human genome for sequences similar to other members of the GLUT family. It contains an N-terminal dileucine motif, that is responsible for intracellular retention of the protein when overexpressed in primary rat adipocytes. Studies have shown that the expression of GLUT6 is predominantly detected in the brain, spleen, and leucocytes and is decreased with phenotypic switching from a proliferative to differentiated state in vascular smooth muscle cells. What’s more, alterations in GLUT6 expression have been linked to numerous cancers. It has been reported that GLUT6 is upregulated in multiple cancers tissues when compared to normal people, such as cutaneous melanoma, medullary breast carcinoma, oesophageal cancer, and head and neck squamous cell carcinoma.

Fig.1 Glucose Transporter in the Membrane.

Application SLC2A6 of Membrane Protein in Literature

Byrne F.L., et al. Knockout of glucose transporter GLUT6 has minimal effects on whole-body metabolic physiology in mice. American Journal of Physiology-Endocrinology and Metabolism. 2018, 315(2):E286-E293. PubMed ID: 29664675

This article aims to investigate how the loss of GLUT6 affects whole-body glucose homeostasis and metabolic physiology. It suggests that GLUT6 is not a major regulator of whole-body metabolic physiology; therefore, GLUT6 inhibition may have minimal adverse effects if targeted for cancer therapy.
Clark J.S., et al. Species differences in Cl^- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. The Journal of physiology. 2008, 586(5):1291-306. PubMed ID: 18174209

This report proposes a hypothesis that the low extracellular Cl(-) affinity and apparent electroneutrality of oxalate efflux characterizing human SLC2A6 may partially explain the high human susceptibility to nephrolithiasis relative to that of the mouse. SLC26A6 sequence variant(s) are candidate risk modifiers for nephrolithiasis.
Lisinski I., et al. Targeting of GLUT6 (formerly GLUT9) and GLUT8 in rat adipose cells. Biochemical Journal. 2001, 358(2):517-22. PubMed ID: 11513753

This article suggests that GLUT6 and GLUT8 appear to recycle in a dynamin-dependent manner between internal membranes and the plasma membrane in rat adipose cells, but are unresponsive to stimuli that induce translocation of GLUT4.

SLC2A6 Preparation Options

To provide high-quality products, we have developed an advanced Magic™ membrane protein production platform. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC2A6 antibody development services.

With extensive experience and professional scientists, Creative Biolabs is dedicated to promoting global customers’ programs. Except for SLC2A6 membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

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