SLC2A9 Membrane Protein Introduction

Introduction of SLC2A9

Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9), also known as glucose transporter type 9 (GLUT-9), is a protein that in humans is encoded by the SLC2A9 gene. As a member of the SLC2A facilitative glucose transporter family which play a significant role in maintaining glucose homeostasis, SLC2A9 is associated with the development and survival of chondrocytes in cartilage matrices.

Basic Information of SLC2A9
Protein Name	Solute carrier family 2, facilitated glucose transporter member 9
Gene Name	SLC2A9
Aliases	Glucose transporter type 9, GLUT-9
Organism	Homo sapiens (Human)
UniProt ID	Q9NRM0
Transmembrane Times	12
Length (aa)	540
Sequence	MARKQNRNSKELGLVPLTDDTSHAGPPGPGRALLECDHLRSGVPGGRRRKDWSCSLLVASLAGAFGSSFLYGYNLSVVNAPTPYIKAFYNESWERRHGRPIDPDTLTLLWSVTVSIFAIGGLVGTLIVKMIGKVLGRKHTLLANNGFAISAALLMACSLQAGAFEMLIVGRFIMGIDGGVALSVLPMYLSEISPKEIRGSLGQVTAIFICIGVFTGQLLGLPELLGKESTWPYLFGVIVVPAVVQLLSLPFLPDSPRYLLLEKHNEARAVKAFQTFLGKADVSQEVEEVLAESRVQRSIRLVSVLELLRAPYVRWQVVTVIVTMACYQLCGLNAIWFYTNSIFGKAGIPPAKIPYVTLSTGGIETLAAVFSGLVIEHLGRRPLLIGGFGLMGLFFGTLTITLTLQDHAPWVPYLSIVGILAIIASFCSGPGGIPFILTGEFFQQSQRPAAFIIAGTVNWLSNFAVGLLFPFIQKSLDTYCFLVFATICITGAIYLYFVLPETKNRTYAEISQAFSKRNKAYPPEEKIDSAVTDGKINGRP

Function of SLC2A9 Membrane Protein

SLC2A9 or Glut9 is a voltage sensitive urate transporter which is almost expressed in the kidney and liver and at low levels in the small intestine, placenta, lung, and leucocytes. To date, two transcript variants encoding distinct isoforms have been identified namely GLUT9a and GLUT9b. GLUT9b is mainly expressed in the kidney, placenta, and liver, whereas GLUT9a shows a broader tissue distribution. In addition to playing a role in the development and survival of chondrocytes in cartilage matrices, SLC2A9 has also been identified as a key component for renal re-absorption of uric acid. It has been reported that the increased expression of SLC2A9 is associated with hyperuricemia and gout, whereas loss of function leads to severe hypouricemia. What’s more, studies have shown that genetic variants of the SLC2A9 transporter have been linked to increased risk of development of numerous diseases, such as hyperuricemia, gout and Alzheimer's disease.

Fig.1 A schematic diagram of the mechanism underlying the neuroprotective effects of urate on dopaminergic neurons. (Bi, 2018)

Application SLC2A9 of Membrane Protein in Literature

Claverie-Martin F., et al. URAT1 and GLUT9 mutations in Spanish patients with renal hypouricemia. Clinica Chimica Acta. 2018, 481:83-9. PubMed ID: 29486147

This article is the first report describing SLC22A12 and SLC2A9 mutations in Spanish patients.
Torres R.J. and Puig J.G. GLUT 9 influences uric acid concentration in patients with Lesch-Nyhan disease. International journal of rheumatic diseases. 2018, 21(6):1270-6. PubMed ID: 29879316

This article aims to investigate whether GLUT9, ABCG2 and URAT1 gene single nucleotide polymorphisms (SNPs) are able to influence uric acid levels and allopurinol response in patients with hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency. It suggests that GLUT9 SNPs could influence the renal handling of uric acid and modulate serum urate levels and the response to treatment in patients with uric acid overproduction due to HPRT deficiency.
Han X.I., et al. Overexpression of uric acid transporter SLC2A9 inhibits proliferation of hepatocellular carcinoma cells. Oncology research. 2018. PubMed ID: 29523220

This research is conducted to study the roles and mechanisms of SLC2A9 in hepatocellular carcinoma (HCC). The results demonstrate that SLC2A9 may be a novel tumor suppressor gene and a potential therapeutic target in HCC.
Long W., et al. Identification of Key Residues for Urate Specific Transport in Human Glucose Transporter 9 (hSLC2A9). Scientific Reports. 2017, 7:41167. PubMed ID: 28117388

This article indicates that urate transport in hSLC2A9 involves several structural elements rather than just a unique substrate binding pocket.
Bu P., et al. Hormonal and chemical regulation of the Glut9 transporter in mice. Journal of Pharmacology and Experimental Therapeutics. 2017, 360(1):206-14. PubMed ID: 27807007

This article demonstrates that Glut9 expression is downregulated by male-pattern growth hormone secretion but is upregulated by activation of aryl hydrocarbon receptor and peroxisome proliferator-activated receptor α signaling in mice.

SLC2A9 Preparation Options

To provide high-quality products, we have developed an advanced Magic™ membrane protein production platform. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC2A9 antibody development services.

With extensive experience and professional scientists, Creative Biolabs is dedicated to promoting global customers’ programs. Except for SLC2A9 membrane protein products, we also provide other membrane protein preparation services to meet every client’s specific requirements. To learn more information, please feel free to contact us for more information.

Reference

Bi, et al. (2018). Glut9-mediated Urate Uptake Is Responsible for Its Protective Effects on Dopaminergic Neurons in Parkinson’s Disease Models. Frontiers in molecular neuroscience. 11: 21.

All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.

	USA: Europe: Germany:
	Call us at: USA: UK: Germany:
	Fax:
	Email: