SLC41A2 Membrane Protein Introduction

Introduction of SLC41A2

Solute carrier family 41 member 2 (SLC41A2) is a transmembrane protein that in human is encoded by SLC41A2 gene. SLC41A2 belongs to the solute carrier family 41 (SLC41), which is linked to Mg²⁺ transport in human cells. Like the other two family member (SLC41A1 and A3), SLC41A2 protein has distant homology to the prokaryotic Mg²⁺ transfer protein termed as MgtE. SLC41A2 protein is widely expressed in normal human tissues, including lymph nodes, lungs, stomach, testis, and skin with the highest expression level, followed by heart, intestine, spleen, kidneys and breast showing moderate expression.

Basic Information of SLC41A2
Protein Name	Solute carrier family 41 member 2
Gene Name	SLC41A2
Aliases	N/A
Organism	Homo sapiens (Human)
UniProt ID	Q96JW4
Transmembrane Times	11
Length (aa)	573
Sequence	MTNSKGRSITDKTSGGPSSGGGFVDWTLRLNTIQSDKFLNLLLSMVPVIYQKNQEDRHKKANGIWQDGLSTAVQTFSNRSEQHMEYHSFSEQSFHANNGHASSSCSQKYDDYANYNYCDGRETSETTAMLQDEDISSDGDEDAIVEVTPKLPKESSGIMALQILVPFLLAGFGTVSAGMVLDIVQHWEVFRKVTEVFILVPALLGLKGNLEMTLASRLSTAVNIGKMDSPIEKWNLIIGNLALKQVQATVVGFLAAVAAIILGWIPEGKYYLDHSILLCSSSVATAFIASLLQGIIMVGVIVGSKKTGINPDNVATPIAASFGDLITLAILAWISQGLYSCLETYYYISPLVGVFFLALTPIWIIIAAKHPATRTVLHSGWEPVITAMVISSIGGLILDTTVSDPNLVGIVVYTPVINGIGGNLVAIQASRISTYLHLHSIPGELPDEPKGCYYPFRTFFGPGVNNKSAQVLLLLVIPGHLIFLYTIHLMKSGHTSLTIIFIVVYLFGAVLQVFTLLWIADWMVHHFWRKGKDPDSFSIPYLTALGDLLGTALLALSFHFLWLIGDRDGDVGD

Function of SLC41A2 Membrane Protein

Intracellular magnesium, especially the ionized fraction (Mg²⁺), is one of the most major intracellular divalent cations and is required for the regulation of a wide variety of cellular functions. Previous data from numerous studies have illustrated that Mg²⁺ transporters played crucial roles in pathways that are involved in cell signaling, metabolism, growth, and proliferation. The SLC41 family of vertebrate magnesium transporters is identified as a unique family among the SLC superfamily, which comprises 44 families of proteins involved in the transport of numerous inorganic and organic solutes. According to a study that expressed SLC41A2 in Xenopus oocytes, SLC41A2 is proved to be an Mg²⁺ channel that might be involved in cellular magnesium homeostasis. Although there is only very limited knowledge on the molecular biology, physiology and exact functions of SLC41A2, this protein indeed acts as a plasma membrane Mg²⁺ transporter. Currently, no link has been established between SLC41A2 protein and any known diseases.

Fig.1 Mg²⁺ transporters in vertebrate cells. (Sahni, 2013)

Application of SLC41A2 Membrane Protein in Literature

Fleig Y., et al. Solute Carrier Family SLC41, What Do We Really Know About It? Wiley Interdiscip Rev Membr Transp Signal. 2013, 2(6). PubMed ID: 24340240

This study aims to explore the transcriptomics, cellular localization, topology, function, and related human diseases of the three numbers of the SLC41 family.
Sahni J., et al. The SLC41 Family of MgtE-like Magnesium Transporters. Mol Aspects Med. 2013, 34(2-3): 620-8. PubMed ID: 23506895

Authors of this article focus on the SLC41 family of magnesium transporters, including SLC41A1-A3.
Sahni J., et al. SLC41A2 encodes a plasma-membrane Mg²⁺ transporter. Biochem J. 2007, 401(2): 505-13. PubMed ID: 16984228

The results of this study suggest that SLC41A2 protein functions as a plasma-membrane Mg²⁺ transporter in vertebrate cells.
Goytain A. and Quamme G.A. Functional characterization of the mouse [corrected] solute carrier, SLC41A2. Biochem Biophys Res Commun. 2007, 356(3): 822. PubMed ID: 15809054

This article demonstrates that SLC41A2 acts as a plasma-membrane Mg²⁺ transporter in vertebrate cells.

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Reference

Sahni J and Scharenberg A M. (2013). The SLC41 family of MgtE-like magnesium transporters.Molecular aspects of medicine. 34(2-3), pp.620-628.

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