SLC41A3 Membrane Protein Introduction

Introduction of SLC41A3

Solute carrier family 41 member 3 (SLC41A3) is a transmembrane protein that in human is encoded by SLC41A3 gene. Solute carrier family 41 member 3 belongs to the solute carrier family 41 (SLC41). SLC41 family consists of three members A1, A2, and A3. Like SLC41A1 and A2, the SLC41A3 protein comprises two “MgtE-like domains” displaying homology to the prokaryotic Mg²⁺ transporter, termed as the MgtE. For SLC41A3 protein, it is broadly expressed in liver, duodenum, colon, small intestine, stomach, urinary bladder, brain and etc.

Basic Information of SLC41A3
Protein Name	Solute carrier family 41 member 3
Gene Name	SLC41A3
Aliases	N/A
Organism	Homo sapiens (Human)
UniProt ID	Q96GZ6
Transmembrane Times	10
Length (aa)	507
Sequence	MDGTETRQRRLDSCGKPGELGLPHPLSTGGLPVASEDGALRAPESQSVTPKPLETEPSRETTWSIGLQVTVPFMFAGLGLSWAGMLLDYFQHWPVFVEVKDLLTLVPPLVGLKGNLEMTLASRLSTAANTGQIDDPQEQHRVISSNLALIQVQATVVGLLAAVAALLLGVVSREEVDVAKVELLCASSVLTAFLAAFALGVLMVCIVIGARKLGVNPDNIATPIAASLGDLITLSILALVSSFFYRHKDSRYLTPLVCLSFAALTPVWVLIAKQSPPIVKILKFGWFPIILAMVISSFGGLILSKTVSKQQYKGMAIFTPVICGVGGNLVAIQTSRISTYLHMWSAPGVLPLQMKKFWPNPCSTFCTSEINSMSARVLLLLVVPGHLIFFYIIYLVEGQSVINSQTFVVLYLLAGLIQVTILLYLAEVMVRLTWHQALDPDNHCIPYLTGLGDLLGSSSVGHTAAVPRRCTASPGWGLIQPFICTQHLIVSLLSFYFPFCLLAKTSI

Function of SLC41A3 Membrane Protein

Currently, there is only very limited knowledge on the molecular biology and exact functions of SLC41A3. However, SLC41A3 protein has been identified as the first mammalian mitochondrial Mg²⁺ efflux system. And this efflux mechanism is temperature sensitive and Na⁺-dependent. Flexible, yet tightly regulated, intracellular Mg²⁺ homeostasis (IMH) is required for the significant role of Mg²⁺ (magnesium) in normal cellular physiology. Clinical studies have suggested that administration of magnesium can ensure cardioprotective benefits during acute myocardial infarction (MI) as well as suppression of cardiac arrhythmias. It has been demonstrated that the addition of magnesium during and prior to cardiac injury such as ischemia-reperfusion may significantly diminish ischemic damage. Some researches have shown that SLC41A1-A3 family has been identified as one of the key magnesium/sodium exchange channels. Further, voltage-gated K⁺ channel beta 2 (Kvβ2) subunit is proved to be a novel regulator to SLC41A3 and plays an essential role in SLC41A3 expression as well as function within the heart.

Fig.1 Computer predicted-model (TMPred) of SLC41A3 topology. (Fleig, 2013)

Application of SLC41A3 Membrane Protein in Literature

Pilchova I., et al. The Involvement of Mg²⁺ in Regulation of Cellular and Mitochondrial Functions. Oxid Med Cell Longev. 2017, 2017: 6797460. PubMed ID: 28757913

This article summarized the effects of Mg²⁺ on mitochondrial functions and showed that mitochondrial extruder SLC41A3 was involved in the regulation of the whole-body Mg²⁺ balance.
de Baaij J.H., et al. Identification of SLC41A3 as a Novel Player in Magnesium Homeostasis. Sci Rep. 2016, 6: 28565. PubMed ID: 27349617

This study found that SLC41A3 was a new factor for Mg(2+) handling.
Mastrototaro L., et al. Solute Carrier 41A3 Encodes For a Mitochondrial Mg(2+) Efflux System. Sci Rep. 2016, 6: 27999. PubMed ID: 27302215

Authors of this article identified SLC41A3 as the first mammalian mitochondrial Mg(2+) efflux system, which significantly enhanced the understanding of intracellular Mg(2+) homeostasis.
Fleig Y., et al. Solute Carrier Family SLC41, What Do We Really Know About It? Wiley Interdiscip Rev Membr Transp Signal. 2013, 2(6). PubMed ID: 24340240

This study attempted to investigate the transcriptomics, cellular localization, topology, function, and related human diseases of the three numbers of the SLC41 family.

SLC41A3 Preparation Options

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Reference

Fleig A, et al.(2013). Solute carrier family SLC41: what do we really know about it? Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 2(6), pp.227-239.

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