SLC6A14 Membrane Protein Introduction

Introduction of SLC6A14

SLC6A14 is encoded by SLC6A14 gene. It belongs to the solute carrier family 6 which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. SLC6A14 is an amino acid transporter and expressed on the apical membrane of epithelial cells. It is hypothesized that this amino acid transporter is principally involved in nutrient uptake, due to its broad specificity and concentrative transport mechanisms. Meanwhile, many studies conducted on SLC6A14 show that it is related to various diseases, such as body mass index quantitative trait locus 11 and meconium ileus.

Basic Information of SLC6A14
Protein Name	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Gene Name	SLC6A14
Aliases	BMIQ11
Organism	Homo sapiens (Human)
UniProt ID	Q9UN76
Transmembrane Times	12
Length (aa)	642
Sequence	MDKLKCPSFFKCREKEKVSASSENFHVGENDENQDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLFFLECSLGQFASLGPVSVWRILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWKNCSSWSDKNCSRSPIVTHCNVSTVNKGIQEIIQMNKSWVDINNFTCINGSEIYQPGQLPSEQYWNKVALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVVYFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGLVALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAYPEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFLLGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWWRACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKGNIFQRLISCCRPASNWGPYLEQHRGERYKDMVDPKKEADHEIPTVSGSRKPE

Function of SLC6A14 Membrane Protein

SLC6A14, also named as solute carrier family 6 (neurotransmitter transporter), member 14, is a Na⁺/Cl^- dependent neutral and cationic amino acid transporter. It is mainly found in lung, salivary gland, and stomach. Recent studies have indicated that SLC6A14 variants are associated with many diseases including X-linked obesity, cystic fibrosis. It plays an important role in clinical therapy. In addition, SLC6A14 has been studied as a potential drug target in various epithelial cancers, such as colon, ovarian, breast and pancreas.

SLC6A14 Membrane Protein Introduction Fig.1 SLC6A14 mRNA and protein expression are up-regulated in pancreatic cancer. (Coothankandaswamy, 2016)

Application of SLC6A14 Membrane Protein in Literature

Ahmadi S., et al. SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion. Elife. 2018, 7: e37963. PubMed ID: 30004386

This article analyzes the expression level of SLC6A14 in mice with cystic fibrosis (CF). These results indicate that SLC6A14 is highly expressed in mice and it could be a therapeutic target for clinic.
Pereira S.V.N., et al. Interaction among variants in the SLC gene family (SLC6A14, SLC26A9, SLC11A1, and SLC9A3) and CFTR mutations with clinical markers of cystic fibrosis. Pediatr Pulmonol. 2018, 53(7): 888-900. PubMed ID: 29635781

This article reports the relationship between SLC gene family (SLC6A14, SLC26A9, SLC11A1, and SLC9A3) as well as CFTR mutations and pancreatic insufficiency (PI). These results indicate that several variants including rs3788766, rs7512462 and rs17235416 could be potential diversity causes of cystic fibrosis.
Di Paola M., et al. SLC6A14 is a genetic modifier of cystic fibrosis that regulates pseudomonas aeruginosa attachment to human bronchial epithelial cells. MBio. 2017, 8(6):e02073-17. PubMed ID: 29259090

Authors in this group examine the expression of SLC6A14 in airway epithelia. The data suggest SLC6A14 plays an important role in host defense by depleting extracellular arginine.
Pereira S.V., et al. Association of clinical severity of cystic fibrosis with variants in the SLC gene family (SLC6A14, SLC26A9, SLC11A1 and SLC9A3). Gene. 2017, 629:117-126. PubMed ID: 28756021

Authors in this group examine the gene polymorphism of SLC gene family (SLC6A14, SLC26A9, SLC11A1, and SLC9A3) in patients who suffer from cystic fibrosis. The results show that CF is strongly related with the variants in these SLC genes.
Coothankandaswamy V., et al. Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer. Br J Pharmacol. 2016, 173(23): 3292-3306. PubMed ID: 27747870

This article analyzes the expression of SLC6A14 in pancreatic cancer. These results indicate that a SLC6A14 blocker can reduce growth and proliferation of pancreatic cancer cells. Meanwhile, SLC6A14 can be used as a novel target for pancreatic cancer.

SLC6A14 Preparation Options

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Reference

Coothankandaswamy V, et al. (2016). Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer. Br J Pharmacol. 173(23), 3292-3306.

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