SLC6A18 Membrane Protein Introduction

Introduction of SLC6A18

SLC6A18 is encoded by SLC6A18 gene. It belongs to the solute carrier family 6 which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It transports small organic solutes, such as neurotransmitters, amino acids, and osmolytes across the plasma membrane. Studies conducted on SLC6A18 show that the Na⁺ cotransporter of neutral amino acids defects of SLC6A18 are related to a wide range of illness, such as iminoglycinuria and hartnup disorder.

Basic Information of SLC6A18
Protein Name	Sodium-dependent neutral amino acid transporter B(0)AT3
Gene Name	SLC6A18
Aliases	XTRP2
Organism	Homo sapiens (Human)
UniProt ID	Q96N87
Transmembrane Times	12
Length (aa)	628
Sequence	MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRDRDARPDTDMRPDTDTRPDTDMRPDTDMR

Function of SLC6A18 Membrane Protein

SLC6A18, also named as solute carrier family 6 (neurotransmitter transporter), member 18, is a sodium and chloride-dependent neutral amino acid transporter. It is expressed exclusively on the luminal membrane of kidney proximal tubules and displays approximately 50% identity with Slc6a19 (B(0)AT1) which is the main neutral amino acid transporter in both kidney and small intestine. Recent studies indicate that the SLC6A18 or neighboring genes are associated with increased susceptibility to myocardial infarction. In addition, research suggests the Slc6a18 transporter is involved in glycine reabsorption and the absence of this transporter is sufficient to cause hypertension.

SLC6A18 Membrane Protein Introduction Fig.1 Role of the SLC6 NTTs in synaptic transmission. (Kristensen, 2011)

Application of SLC6A18 Membrane Protein in Literature

Soma S., et al. Spatial mRNA expression and response to fasting and refeeding of neutral amino acid transporters slc6a18 and slc6a19a in the intestinal epithelium of mozambique tilapia. Front Physiol. 2018, 9:212. PubMed ID: 29593569

This article analyzes the expression levels of slc6a18 and slc6a19a in the five segments (HL, PMC, GL, DMC, and TS) of the intestine of Mozambique tilapia. These results indicate that slc6a18 is mainly expressed in the middle (GL) and posterior (DMC and TS) intestines, while slc6a19a is specifically expressed in the anterior intestine (HL and PMC).
Matsumoto K., et al. Association study: SLC6A18 gene and myocardial infarction. Clin Biochem. 2011, 44(10-11): 789-94. PubMed ID: 21420947

This article reports the relationship between the human SLC6A18 gene and myocardial infarction (MI) in a Japanese population. The data indicate that the CC+CG genotype of SLC6A18 rs7447815 could be involved in the pathogenesis of myocardial infarction.
Friedman E., et al. Novel candidate genes putatively involved in stress fracture predisposition detected by whole-exome sequencing. Genet Res (Camb). 2014, 96:e004. PubMed ID: 25023003

Authors in this group conduct a whole exome sequence to identify the genetic alterations which are related to stress fracture. The data demonstrate that three missense mutations (rs7426114, rs4073918, rs3752135 in the NEB, SLC6A18 and SIGLEC12 genes, respectively) and three synonymous mutations (rs2071856, rs2515941, rs716745 in the ELFN2, GRK4, LRRC55 genes) should be potential targets for SF diagnosis.

SLC6A18 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC6A18 antibody development services.

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Reference

Kristensen A S, et al. (2011). SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol Rev. 63(3), 585-640.

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