SLC6A6 Membrane Protein Introduction

Introduction of SLC6A6

SLC6A6 is encoded by SLC6A6 gene. It belongs to the solute carrier family 6 which has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. It is a sodium- and chloride-dependent taurine transporter which is responsible for the transport of taurine and beta-alanine. It needs at least 2 Na⁺ ions and 1 Cl^- ion to remove taurine across the cell membrane. Taurine is the most abundant amino acid in human placenta implying an important physiological role within this tissue. Meanwhile, many studies conducted on SLC6A6 show that its variants are related to cerebral creatine deficiency syndrome.

Basic Information of SLC6A6
Protein Name	Sodium- and chloride-dependent taurine transporter
Gene Name	SLC6A6
Aliases	TauT
Organism	Homo sapiens (Human)
UniProt ID	P31641
Transmembrane Times	12
Length (aa)	620
Sequence	MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELPWAHCNHSWNTPHCMEDTMRKNKSVWITISSTNFTSPVIEFWERNVLSLSPGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGAGIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTYNKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLLTPREPNRWAVEREGATPYNSRTVMNGALVKPTHIIVETMM

Function of SLC6A6 Membrane Protein

SLC6A6, also named as the taurine transporter (TauT), is usually expressed in the skeletal, heart, muscle, brain, retina, kidney, placenta as well as thyroid. SLC6A6 plays an important role in cell volume regulation, antioxidant release, immunomodulation, and protein stabilization. Recent studies indicate that SLC6A6 variants are strongly associated with retinal degeneration. In addition, researches have confirmed that SLC6A6 deficient is involved in various function abnormalities, including vision loss, reduced fertility and body weights in mice.

SLC6A6 Membrane Protein Introduction Fig.1 TauT is involved in taurine transport across the blood-retinal barrier.

Application of SLC6A6 Membrane Protein in Literature

Tachikawa M., et al. Assembly of Taurine transporter (Slc6a6) with Na⁺-H⁺ exchanger regulatory factor 1 (Slc9a3r1) improves GABA transport activity by increasing the maximum transport velocity. Biol Pharm Bull. 2018, 41(3): 338-341. PubMed ID: 29491210

This article aims to identify the assembly of taurine transporter (TauT/Slc6a6) and PSD-95/Disc-large/Zo-1 (PDZ) domain of Na⁺-H⁺ exchanger regulatory factor 1 (NHERF1) as a regulatory mechanism of TauT-mediated GABA transport activity. These results indicate that the assembly of TauT and PDZ-binding motif of NHERF1 increases the maximal transport velocity of GABA rather than changes the affinity.
Tran T.T., et al. Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells. Photochem Photobiol. 2014, 90(5):1136-43. PubMed ID: 24842606

This article analyzes the expression level of SLC6A6 and SLC6A13 in HEK293T cells. The data suggest that SLC6A6 and SLC6A13 are important for the enhancement of ALA-induced protoporphyrin accumulation in cancerous cells.
Yasunaga M., et al. Role of SLC6A6 in promoting the survival and multidrug resistance of colorectal cancer. Sci Rep. 2014, 4: 4852. PubMed ID: 24781822

Authors in this group analyze the association between SLC6A6 and the survival and multidrug resistance of colorectal cancer (CRC). The data show that SLC6A6 plays an important role in the maintenance of CSC characteristics.

SLC6A6 Preparation Options

To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-SLC6A6 antibody development services.

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